TIFAB - TIFA inhibitor Gene

Homo sapiens

Gene ID: 497189 | Gene type: protein coding

About TIFAB

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,444,226-135,452,351 (from NCBI)

This gene has 1 transcript (splice variant), 73 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 4.5), appendix (RPKM 3.4) and 12 other tissues.

Summary

TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

TIFAB Products(1)

mRNA	Protein	Name
NM_001099221.2	NP_001092691.1	TRAF-interacting protein with FHA domain-containing protein B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15047173	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in auditory behavior	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in cochlea development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in craniofacial suture morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in genitalia development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in genitalia morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in hard palate morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in inner ear development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in learned vocalization behavior	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in mastication	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in negative regulation of relaxation of muscle	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in negative regulation of saliva secretion	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in peristalsis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in regulation of muscle organ development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in thorax and anterior abdomen determination	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in trigeminal nerve development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in vestibulocochlear nerve formation	IGI IGI: Inferred from genetic interaction	23419067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIFAB Protein Structure

FHA

0
100
161 a.a.

Protein Preferred Names

Protein Names

TRAF-interacting protein with FHA domain-containing protein B

TIFA-like protein

TIFAB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIFAB	Q6ZNK6	USP15	Homo sapiens	Q9Y4E8	Anti Tag CoIP	32101751
Intra	TIFAB	Q6ZNK6	USP15	Homo sapiens	Q9Y4E8	TAP	32101751
Intra	TIFAB	Q6ZNK6	TIFA	Homo sapiens	Q96CG3	TAP	32101751

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14522	TIFAB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIFAB	VGNC	VGNC:47367
Mus musculus	TIFAB	MGD	MGI:2385852
Felis catus	TIFAB	VGNC	VGNC:102344
Rattus norvegicus	TIFAB	RGD	RGD:1311681
Macaca mulatta	TIFAB	VGNC	VGNC:79944
Bos taurus	TIFAB	VGNC	VGNC:52889

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