2. Gene
  3. USP15 - ubiquitin specific peptidase 15 Gene

USP15 - ubiquitin specific peptidase 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UNPH4; UNPH-2

Gene ID: 9958 | Gene type: protein coding

About USP15

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:62,260,404-62,416,389 (from NCBI)

This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues.

Summary

This gene encodes a member of the ubiquitin specific Protease (USP) family of deubiquitinating Enzymes. USP Enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

USP15 Products(11)

mRNA Protein Name
NM_001252078.2 NP_001239007.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 1
NM_001252079.2 NP_001239008.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 3
NM_001351159.2 NP_001338088.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 4
NM_001351160.2 NP_001338089.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 5
NM_001351161.2 NP_001338090.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 6
NM_001351162.2 NP_001338091.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 7
NM_001351163.2 NP_001338092.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351164.2 NP_001338093.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351165.2 NP_001338094.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351166.2 NP_001338095.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_006313.3 NP_006304.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
24399297 GOA
enables SMAD binding IPI
IPI: Inferred from physical interaction
21947082 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
16005295 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21947082 GOA
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
32839293 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22001210 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21209336 GOA
enables transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
22344298 GOA
enables ubiquitin-modified histone reader activity IDA
IDA: Inferred from direct assay
24526689 GOA
Biological Process GO Annotation Evidence Reference Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
21947082 GOA
involved in monoubiquitinated protein deubiquitination IDA
IDA: Inferred from direct assay
21947082 GOA
involved in negative regulation of antifungal innate immune response IDA
IDA: Inferred from direct assay
33093067 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22344298 GOA
involved in positive regulation of RIG-I signaling pathway IDA
IDA: Inferred from direct assay
24399297 GOA
involved in protein K27-linked deubiquitination IDA
IDA: Inferred from direct assay
33093067 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
16005295 GOA
involved in transcription elongation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
24526689 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
21947082 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21947082 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21947082 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP15 Protein Structure

DUSP

DUSP: DUSP domain (27 - 118)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (136 - 222)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (288 - 930)

  • 0
  • 200
  • 400
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  • 800
  • 981 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 15

deubiquitinating enzyme 15

Related Diseases

Diseases Alias
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148046 USP15-IN-1 Inhibitor 99.42% Unkown
HY-RS15526 USP15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP15 VGNC VGNC:66869
Bos taurus USP15 VGNC VGNC:36713
Macaca mulatta USP15 VGNC VGNC:78737
Mus musculus USP15 MGD MGI:101857
Rattus norvegicus USP15 RGD RGD:628795
Canis familiaris USP15 VGNC VGNC:48180
Others USP15 NCBI