2. Gene
  3. OPRK1 - opioid receptor kappa 1 Gene

OPRK1 - opioid receptor kappa 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1

Gene ID: 4986 | Gene type: protein coding

About OPRK1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,225,724-53,251,637 (from NCBI)

This gene has 5 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues.

Summary

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

OPRK1 Products(3)

mRNA Protein Name
NM_000912.5 NP_000903.2 kappa-type opioid receptor isoform 1
NM_001282904.2 NP_001269833.1 kappa-type opioid receptor isoform 2
NM_001318497.2 NP_001305426.1 kappa-type opioid receptor isoform 1x

OPRK1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (76 - 330)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

kappa-type opioid receptor

Opiate receptor, kappa-1

OPRK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OPRK1 P41145 APLNR Homo sapiens P35414
BRET
31668922
Intra
OPRK1 P41145 APLNR Homo sapiens P35414
BRET
22200678
Intra
OPRK1 P41145 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
Intra
OPRK1 P41145 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
16431922
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Morphine Dependence
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Cocaine Dependence
Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos
Drug Dependence
Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn
Opioid Abuse

Opioid-Related Disorders
Cocaine Abuse

Cocaine-Related Disorders
Pain Agnosia

Analgesia
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome
Retinitis Pigmentosa 44

RP44

Retinitis Pigmentosa, Type 44
Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23

SCA23

Ataxia, Spinocerebellar, Type 23
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Substance Dependence
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Substance Abuse

Substance-Related Disorders

Substance Abuse Problem
Specific Developmental Disorder
Constipation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09802 OPRK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-116163 ML350 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus OPRK1 VGNC VGNC:68633
Bos taurus OPRK1 VGNC VGNC:32439
Canis familiaris OPRK1 VGNC VGNC:44133
Macaca mulatta OPRK1 VGNC VGNC:104467
Rattus norvegicus OPRK1 RGD RGD:69426
Mus musculus OPRK1 MGD MGI:97439