ORM2 - orosomucoid 2 Gene

Homo sapiens

Also known as AGP2; AGP-B; AGP-B'

Gene ID: 5005 | Gene type: protein coding

About ORM2

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,329,869-114,333,251 (from NCBI)

This gene has 1 transcript (splice variant), 126 orthologues and 1 paralogue. Restricted expression toward liver (RPKM 2828.2).

Summary

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

ORM2 Products(1)

mRNA	Protein	Name
NM_000608.4	NP_000599.1	alpha-1-acid glycoprotein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	8774350	GOA
involved in positive regulation of interleukin-1 production	IDA IDA: Inferred from direct assay	8774350	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	8774350	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8774350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORM2 Protein Structure

Lipocalin

0
100
201 a.a.

Protein Preferred Names

Protein Names

alpha-1-acid glycoprotein 2

AGP 2

ORM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ORM2	P19652	ORM1	Homo sapiens	P02763	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ORM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7490	Orm2 Protein, Human (HEK293, His)	P19652 (Q19-S201)	≥95%

ORM2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83609	ORM2 Antibody (YA3354)	WB, IHC-P	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09832	ORM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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