PAEP - progestagen associated endometrial protein Gene

Homo sapiens

Also known as GD; GdA; GdF; GdS; PEP; PAEG; PP14; ZIF-1

Gene ID: 5047 | Gene type: protein coding

About PAEP

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,561,756-135,566,955 (from NCBI)

This gene has 9 transcripts (splice variants), 154 orthologues and 12 paralogues. Restricted expression toward endometrium (RPKM 125.9).

Summary

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PAEP Products(3)

mRNA	Protein	Name
NM_001018048.2	NP_001018058.1	glycodelin isoform 2 precursor
NM_001018049.3	NP_001018059.1	glycodelin isoform 1 precursor
NM_002571.4	NP_002562.2	glycodelin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	18996219	GOA
involved in negative regulation of sperm capacitation	IMP IMP: Inferred from mutant phenotype	15883155	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	19945098	GOA
involved in regulation of binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	17192260	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	3667877	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAEP Protein Structure

Lipocalin

0
100
180 a.a.

Protein Preferred Names

Protein Names

glycodelin

PEG

Recombinant PAEP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71669	PAEP Protein, Human (HEK293, Myc, His)	P09466-1 (M19-F180)	≥95%
HY-P700004	PAEP Protein, Human (HEK293, His)	P09466-1 (M19-F180)	≥95%

Related Diseases

Diseases

Alias

Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome	KLEFS1
Chromosome 9q34.3 Deletion Syndrome	9q- Syndrome
9q34 Deletion Syndrome	Kleefstra Syndrome Due To 9q34 Microdeletion
Kleefstra Syndrome	9q-Syndrome
9qstds	Kleefstra Syndrome Due To 9q Subtelomeric Deletion
Kleefstra Syndrome Due To Del(9)(Q34)	Kleefstra Syndrome Due To Monosomy 9q34
Chromosome 9q Subtelomeric Deletion Syndrome	Kleefstra Syndrome, Type 1

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Submucous Uterine Fibroid

Submucous Leiomyoma Of Uterus

Ovarian Cyst

Ovarian Cysts

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Pregnancy Loss, Recurrent 1

Pregnancy Loss, Recurrent, Susceptibility To, 1	Rpl
RPRGL1	Rprgl
Recurrent Miscarriage	Recurrent Spontaneous Abortion
Abortion, Spontaneous, Recurrent	Fetal Loss, Recurrent
Fetal Loss, Recurrent, Susceptibility To	Miscarriage, Recurrent
Embryonic Loss, Recurrent	Stillbirth, Recurrent
Pregnancy Loss, Recurrent, 1	Recurrent Embryonic Loss
Recurrent Fetal Loss	Recurrent Stillbirth
Spontaneous Recurrent Abortion	Miscarriage Recurrent
Pregnancy Loss, Recurrent, Susceptibility To, Type 1	Abortion, Habitual

Infertility

Microphthalmia, Isolated 4

Isolated Microphthalmia 4	MCOP4
Microphthalmia, Isolated, 4	Isolated Clinical Anophthalmia
Microphthalmia, Isolated, Type 4

Brachydactyly, Type A1, C

Brachydactyly Type A1c	BDA1C
Brachydactyly A1, C	Brachydactyly A1c
Brachydactyly Type A1 C

Atypical Follicular Adenoma

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome	Rudiger Syndrome 1
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1	EEC1
Eec Syndrome 1	Eec Syndrome-1
Walker-Clodius Syndrome	Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome
Eec	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome	Ectrodactyly-Cleft Lip/Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate	Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome
Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome	Ectrodactyly-Cleft Lip-Palate Syndrome
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome

Proximal Symphalangism

Cushing'S Symphalangism	Symphalangism, Proximal
Hereditary Absence Of Proximal Interphalangeal Joints	Strasburger-Hawkins-Eldridge Syndrome
Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome	Symphalangism, Proximal, 1a
Symphalangism, Proximal, 1b	Vessel'S Syndrome
Symphalangism, Cushing Type

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly	Du Pan Syndrome
AMD2B	Dupans
Acromesomelic Dysplasia-2b	Fibular Aplasia-Complex Brachydactyly Syndrome

Brachydactyly, Type C

Brachydactyly Type C	BDC
Brachydactyly Haws Type	Brachydactyly, Haws Type
Brachydactyly C

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Infiltrating Angiolipoma

Angiolipoma, Infiltrating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09965	PAEP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PAEP	RGD	RGD:2293817
Others	PAEP	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.