Fasn - fatty acid synthase Gene

Rattus norvegicus

Gene ID: 50671 | Gene type: protein coding

About Fasn

Primary_assembly 10: 106,072,091-106,090,261 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 20 phenotypes. Biased expression in Adrenal (RPKM 37.2), Thymus (RPKM 361.4) and 5 other tissues.

Summary

Enables [acyl-carrier-protein] S-malonyltransferase activity and identical protein binding activity. Involved in acetyl-CoA metabolic process and fatty acid biosynthetic process. Located in cytoplasm. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fasn Products(1)

mRNA	Protein	Name
NM_017332.2	NP_059028.2	fatty acid synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables [acyl-carrier-protein] S-malonyltransferase activity	IMP IMP: Inferred from mutant phenotype	8940200	RGD
enables fatty acid synthase activity	IDA IDA: Inferred from direct assay	15715522	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9047334	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16054098	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetyl-CoA metabolic process	IDA IDA: Inferred from direct assay	18062843	RGD
involved in fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	15715522	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	26394137	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25943649	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16054098	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fasn Protein Structure

PksD

PKS

Methyltransf_12

KR_1_FAS_SDR_x

PKS_ER

KR_1_FAS_SDR_x

entF

Thioesterase

0
400
800
1200
1600
2000
2505 a.a.

Protein Preferred Names

Protein Names

fatty acid synthase

type I FAS

Fasn Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	EM	15711565
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	Crosslink	10206962
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	Y2H	11248039
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	Biochemical	11248039
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	GMS	9047334
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	3D-EM	19151726
Intra	Fasn	P12785	Fasn	Rattus norvegicus	P12785	Biochemical	9047334

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0218	Orlistat		99.97%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112829	Denifanstat	Inhibitor	99.58%	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12364	C75	Inhibitor	99.91%	Unkown
HY-120394	TVB-3166		99.69%	Unkown
HY-A0210	Cerulenin		99.52%	Unkown
HY-120062	TVB-3664	Inhibitor	99.57%	Unkown
HY-12325	GSK2194069	Inhibitor	99.84%	Unkown
HY-16100	BI 99179	Inhibitor	99.38%	Unkown
HY-124628	IPI-9119	Inhibitor	99.24%	Unkown
HY-12364A	trans-C75	Inhibitor	99.73%	Unkown
HY-12648A	FASN-IN-4 tosylate	Inhibitor	98.55%	Unkown
HY-N2486	Desoxyrhaponticin		99.80%	Unkown
HY-121250	Fasnall		99.54%	Unkown
HY-111551	FT113	Inhibitor	99.39%	Unkown
HY-B0218R	Orlistat (Standard)		99.85%	Unkown
HY-110354	UCM05	Inhibitor	99.58%	Unkown
HY-111777	FASN-IN-1	Inhibitor	99.90%	Unkown
HY-145809	FASN-IN-5	Inhibitor	99.81%	Unkown
HY-RS04754	Fasn Mouse Pre-designed siRNA Set A		/	Unkown
HY-12648	FASN-IN-4	Inhibitor	99.21%	Unkown
HY-U00436	FASN-IN-3	Inhibitor	98.06%	Unkown
HY-117769	GSK837149A	Inhibitor	≥99.0%	Unkown
HY-112522	HS79	Inhibitor	/	Unkown
HY-112522A	HS80	Inhibitor	/	Unkown
HY-12364B	(−)-C75	Inhibitor	/	Unkown
HY-149540	CTL-06	Inhibitor	/	Unkown
HY-149541	CTL-12	Inhibitor	/	Unkown
HY-155282	FASN-IN-6	Inhibitor	/	Unkown
HY-158649	Fasnall benzenesulfonate		/	Unkown
HY-B0218S	Orlistat-d3		/	Unkown
HY-N8144	Niga-ichigoside F1		≥99.0%	Unkown
HY-RS04753	FASN Human Pre-designed siRNA Set A		/	Unkown
HY-RS04755	Fasn Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fasn	NCBI	NCBI:2194

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