ATP5F1C - ATP synthase F1 subunit gamma Gene

Homo sapiens

Also known as ATP5C; ATP5C1; ATP5CL1

Gene ID: 509 | Gene type: protein coding

About ATP5F1C

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:7,788,177-7,807,801 (from NCBI)

This gene has 10 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in heart (RPKM 224.0), adrenal (RPKM 140.8) and 25 other tissues.

Summary

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the Other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

ATP5F1C Products(3)

mRNA	Protein	Name
NM_001001973.3	NP_001001973.1	ATP synthase subunit gamma, mitochondrial isoform L (liver) precursor
NM_001320886.2	NP_001307815.1	ATP synthase subunit gamma, mitochondrial isoform 3
NM_005174.4	NP_005165.1	ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism	IDA IDA: Inferred from direct assay	12110673	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proton motive force-driven mitochondrial ATP synthesis	IDA IDA: Inferred from direct assay	12110673	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proton-transporting ATP synthase complex	IDA IDA: Inferred from direct assay	12110673	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5F1C Protein Structure

ATP-synt

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

ATP synthase subunit gamma, mitochondrial

ATP synthase gamma chain, mitochondrial

ATP5F1C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP5F1C	P36542	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ATP5F1C	P36542	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ATP5F1C	P36542	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ATP5F1C	P36542	ATP5F1B	Homo sapiens	P06576	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01204	ATP5F1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATP5F1C	VGNC	VGNC:68644
Mus musculus	ATP5F1C	MGD	MGI:1261437
Bos taurus	ATP5F1C	VGNC	VGNC:26301
Rattus norvegicus	ATP5F1C	RGD	RGD:620011
Macaca mulatta	ATP5F1C	VGNC	VGNC:100298

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