PCBP2 - poly(rC) binding protein 2 Gene

Homo sapiens

Also known as HNRPE2; HNRNPE2; hnRNP-E2

Gene ID: 5094 | Gene type: protein coding

About PCBP2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,452,102-53,481,162 (from NCBI)

This gene has 26 transcripts (splice variants), 280 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues.

Summary

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]

PCBP2 Products(7)

mRNA	Protein	Name
NM_001098620.3	NP_001092090.1	poly(rC)-binding protein 2 isoform c
NM_001128911.2	NP_001122383.1	poly(rC)-binding protein 2 isoform d
NM_001128912.2	NP_001122384.1	poly(rC)-binding protein 2 isoform e
NM_001128913.2	NP_001122385.1	poly(rC)-binding protein 2 isoform f
NM_001128914.2	NP_001122386.1	poly(rC)-binding protein 2 isoform g
NM_005016.6	NP_005007.2	poly(rC)-binding protein 2 isoform a
NM_031989.5	NP_114366.1	poly(rC)-binding protein 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	7607214	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19881509	GOA
enables lncRNA binding	IDA IDA: Inferred from direct assay	31361039	GOA
enables promoter-enhancer loop anchoring activity	IMP IMP: Inferred from mutant phenotype	31361039	GOA
enables protein binding	IDA IDA: Inferred from direct assay	35322803	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19881509	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	12414943	GOA
involved in chromatin looping	IMP IMP: Inferred from mutant phenotype	31361039	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	35322803	GOA
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	19881509	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19881509	GOA
involved in viral RNA genome replication	IDA IDA: Inferred from direct assay	12414943	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19029303	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	31361039	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCBP2 Protein Structure

KH_1

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

poly(rC)-binding protein 2

alpha-CP2

PCBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCBP2	Q15366	SRSF3	Homo sapiens	P84103	Anti Bait CoIP	17183366
Intra	PCBP2	Q15366	SRSF3	Homo sapiens	P84103	Y2H	17183366
Intra	PCBP2	Q15366	SNRPA	Homo sapiens	P09012	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PCBP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81798	PCBP2 Antibody (YA1543)	WB, IP	Mouse, Rat

Related Diseases

Diseases

Alias

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10116	PCBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PCBP2	VGNC	VGNC:49069
Rattus norvegicus	PCBP2	RGD	RGD:1309626
Mus musculus	PCBP2	MGD	MGI:108202

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