2. Gene
  3. UBXN1 - UBX domain protein 1 Gene

UBXN1 - UBX domain protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 2B28; SAKS1; UBXD10

Gene ID: 51035 | Gene type: protein coding

About UBXN1

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,676,500-62,679,073 (from NCBI)

This gene has 18 transcripts (splice variants), 197 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 47.6), fat (RPKM 40.5) and 25 other tissues.

Summary

Enables several functions, including Enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and Proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN1 Products(3)

mRNA Protein Name
NM_001286077.2 NP_001273006.1 UBX domain-containing protein 1 isoform 2
NM_001286078.2 NP_001273007.1 UBX domain-containing protein 1 isoform 3
NM_015853.5 NP_056937.2 UBX domain-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
15362974 GOA
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
21135095 GOA
enables K6-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
20351172 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
15362974 GOA
enables proteasome regulatory particle binding IDA
IDA: Inferred from direct assay
15362974 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18775313 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
18775313 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
18775313 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of ERAD pathway IMP
IMP: Inferred from mutant phenotype
21135095 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20351172 GOA
involved in negative regulation of protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
21135095 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
20351172 GOA
involved in negative regulation of ubiquitin-specific protease activity IDA
IDA: Inferred from direct assay
21135095 GOA
Cellular Component GO Annotation Evidence Reference Source
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
18775313 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10942595 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21135095 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21135095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN1 Protein Structure

UBA

UBA: UBA/TS-N domain (6 - 39)

UBX

UBX: UBX domain (209 - 292)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

UBX domain-containing protein 1

SAPK substrate protein 1

UBXN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBXN1 Q04323 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
UBXN1 Q04323 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
UBXN1 Q04323 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
UBXN1 Q04323 UBE2I Homo sapiens Q7KZS0
Validated Y2H
25416956
Intra
UBXN1 Q04323 UBE2I Homo sapiens Q7KZS0
Y2H Array
25416956
Intra
UBXN1 Q04323 PLAA Homo sapiens Q9Y263
Y2H Array
25416956
Intra
UBXN1 Q04323 PLAA Homo sapiens Q9Y263
Anti Tag CoIP
18775313
Intra
UBXN1 Q04323 VCP Homo sapiens P55072
Anti Tag CoIP
18775313
Intra
UBXN1 Q04323 VCP Homo sapiens P55072
Y2H Array
25416956
Intra
UBXN1 Q04323 VCP Homo sapiens P55072
Validated Y2H
25416956
Intra
UBXN1 Q04323 TRIM39 Homo sapiens Q9HCM9
Y2H Array
25416956
Intra
UBXN1 Q04323 TRIM39 Homo sapiens Q9HCM9
Validated Y2H
25416956
Intra
UBXN1 Q04323 q8wu02_human Homo sapiens Q8WU02
Y2H Prey Pooling
25416956
Intra
UBXN1 Q04323 q8wu02_human Homo sapiens Q8WU02
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15394 UBXN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBXN1 MGD MGI:1289301
Bos taurus UBXN1 VGNC VGNC:36622
Rattus norvegicus UBXN1 RGD RGD:1309471
Canis familiaris UBXN1 VGNC VGNC:48095
Macaca mulatta UBXN1 VGNC VGNC:79135
Felis catus UBXN1 VGNC VGNC:66790