TRIM39 - tripartite motif containing 39 Gene

Homo sapiens

Also known as TFP; RNF23; TRIM39B

Gene ID: 56658 | Gene type: protein coding

About TRIM39

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,326,469-30,343,729 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 128 orthologues and 80 paralogues. Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TRIM39 Products(5)

mRNA	Protein	Name
NM_001369521.2	NP_001356450.1	E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_001369522.1	NP_001356451.1	E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_001369523.1	NP_001356452.1	E3 ubiquitin-protein ligase TRIM39 isoform 2
NM_021253.4	NP_067076.2	E3 ubiquitin-protein ligase TRIM39 isoform 1
NM_172016.2	NP_742013.1	E3 ubiquitin-protein ligase TRIM39 isoform 2

TRIM39 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
518 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM39

RING-type E3 ubiquitin transferase TRIM39

Related Diseases

Diseases

Alias

Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases	Telangiectatic Membranoproliferative Glomerulonephritis
HLTRS	Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome
Hlt-Renal Defect Syndrome	Glomerulonephritis Sparse Hair Telangiectases

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15043	TRIM39 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM39	MGD	MGI:1890659
Rattus norvegicus	TRIM39	RGD	RGD:1303115

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