DERA - deoxyribose-phosphate aldolase Gene

Homo sapiens

Also known as DEOC; CGI-26

Gene ID: 51071 | Gene type: protein coding

About DERA

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,911,332-16,037,381 (from NCBI)

This gene has 10 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in small intestine (RPKM 26.2), kidney (RPKM 24.6) and 25 other tissues.

Summary

Enables deoxyribose-phosphate aldolase activity. Involved in deoxyribonucleoside catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DERA Products(2)

mRNA	Protein	Name
NM_001300779.2	NP_001287708.1	deoxyribose-phosphate aldolase isoform 2
NM_015954.4	NP_057038.2	deoxyribose-phosphate aldolase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables deoxyribose-phosphate aldolase activity	IDA IDA: Inferred from direct assay	9226884	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in deoxyribonucleoside catabolic process	IDA IDA: Inferred from direct assay	9226884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DERA Protein Structure

DeoC

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

deoxyribose-phosphate aldolase

2-deoxy-D-ribose 5-phosphate aldolase

DERA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DERA	Q9Y315	ALDH16A1	Homo sapiens	Q8IZ83	Y2H Array	32296183
Intra	DERA	Q9Y315	ALDH16A1	Homo sapiens	Q8IZ83	Anti Tag CoIP	33961781
Intra	DERA	Q9Y315	ALDH16A1	Homo sapiens	Q8IZ83	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mast Syndrome

SPG21	Spastic Paraplegia 21, Autosomal Recessive
Autosomal Recessive Spastic Paraplegia Type 21	Autosomal Recessive Spastic Paraplegia 21
Hereditary Spastic Paraplegia 21

Balanitis Xerotica Obliterans

Penile Lichen Sclerosus

Penile Leukoplakia

Streptococcal Meningitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147061	2-Deoxyribose 5-phosphate disodium		≥95.0%	Unkown
HY-RS03698	DERA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DERA	VGNC	VGNC:61447
Mus musculus	DERA	MGD	MGI:1913762
Bos taurus	DERA	VGNC	VGNC:28009
Macaca mulatta	DERA	VGNC	VGNC:71696
Canis familiaris	DERA	VGNC	VGNC:39901
Rattus norvegicus	DERA	RGD	RGD:1589836

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