PHF20L1 - PHD finger protein 20 like 1 Gene

Homo sapiens

Also known as URLC1; CGI-72; TDRD20B

Gene ID: 51105 | Gene type: protein coding

About PHF20L1

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:132,775,388-132,848,807 (from NCBI)

This gene has 20 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 4.7) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF20L1 Products(4)

mRNA	Protein	Name
NM_001277196.2	NP_001264125.1	PHD finger protein 20-like protein 1 isoform 4
NM_001362971.2	NP_001349900.1	PHD finger protein 20-like protein 1 isoform 4
NM_016018.5	NP_057102.4	PHD finger protein 20-like protein 1 isoform 1
NM_198513.2	NP_940915.1	PHD finger protein 20-like protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylation-dependent protein binding	IPI IPI: Inferred from physical interaction	24492612	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16415788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24492612	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	29358331	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF20L1 Protein Structure

DUF3776

PHD

0
200
400
600
800
1017 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 20-like protein 1

tudor domain containing 20B

PHF20L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PHF20L1	A8MW92	H4C16	Homo sapiens	P62805	Pull Down	16415788
Intra	PHF20L1	A8MW92	H3C1	Homo sapiens	P68431	Pull Down	16415788
Intra	PHF20L1	A8MW92	H3C1	Homo sapiens	P68431	Protein Array	16415788

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cutaneous Adenocystic Carcinoma

Adenoid Cystic Eccrine Carcinoma	Adenoid Cystic Carcinoma Of The Skin
Adenoid Cystic Eccrine Carcinoma Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10422	PHF20L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PHF20L1	VGNC	VGNC:84100
Bos taurus	PHF20L1	VGNC	VGNC:32820
Canis familiaris	PHF20L1	VGNC	VGNC:44486
Mus musculus	PHF20L1	MGD	MGI:2444412
Felis catus	PHF20L1	VGNC	VGNC:64141
Rattus norvegicus	PHF20L1	RGD	RGD:1560141

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