METTL9 - methyltransferase like 9 Gene

Homo sapiens

Also known as DREV; PAP1; DREV1; CGI-81; hMETTL9

Gene ID: 51108 | Gene type: protein coding

About METTL9

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:21,597,208-21,657,471 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele and 199 orthologues. Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues.

Summary

Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

METTL9 Products(4)

mRNA	Protein	Name
NM_001077180.3	NP_001070648.1	protein-L-histidine N-pros-methyltransferase isoform 2 precursor
NM_001288659.2	NP_001275588.1	protein-L-histidine N-pros-methyltransferase isoform 3
NM_001288660.2	NP_001275589.1	protein-L-histidine N-pros-methyltransferase isoform 4
NM_016025.5	NP_057109.3	protein-L-histidine N-pros-methyltransferase isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21784977	GOA
enables protein-L-histidine N-pros-methyltransferase activity	IDA IDA: Inferred from direct assay	33563959	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	33563959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL9 Protein Structure

DREV

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

protein-L-histidine N-pros-methyltransferase

CTB-31N19.3

METTL9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	METTL9	Q9H1A3	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 22

DFNB22	Autosomal Recessive Nonsyndromic Deafness 22
Autosomal Recessive Deafness 22	Deafness, Autosomal Recessive, 22
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 22	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 22

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08371	METTL9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	METTL9	VGNC	VGNC:31418
Mus musculus	METTL9	MGD	MGI:1914862
Macaca mulatta	METTL9	VGNC	VGNC:74568
Canis familiaris	METTL9	VGNC	VGNC:43183
Felis catus	METTL9	VGNC	VGNC:97507
Rattus norvegicus	METTL9	RGD	RGD:2311609

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