NAA20 - N-alpha-acetyltransferase 20, NatB catalytic subunit Gene

Homo sapiens

Also known as NAT3; NAT5; MRT73; NAT3P; NAT5P; dJ1002M8.1

Gene ID: 51126 | Gene type: protein coding

About NAA20

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,017,290-20,033,655 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 49.8), testis (RPKM 35.7) and 25 other tissues.

Summary

NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

NAA20 Products(3)

mRNA	Protein	Name
NM_016100.5	NP_057184.1	N-alpha-acetyltransferase 20 isoform a
NM_181527.3	NP_852668.1	N-alpha-acetyltransferase 20 isoform b
NM_181528.3	NP_852669.1	N-alpha-acetyltransferase 20 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18570629	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-terminal peptidyl-aspartic acid acetylation	IDA IDA: Inferred from direct assay	34230638	GOA
involved in N-terminal peptidyl-glutamic acid acetylation	IDA IDA: Inferred from direct assay	34230638	GOA
involved in N-terminal peptidyl-glutamine acetylation	IDA IDA: Inferred from direct assay	34230638	GOA
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	34230638	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NatB complex	IPI IPI: Inferred from physical interaction	18570629	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18570629	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25732826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA20 Protein Structure

Acetyltransf_1

0
100
178 a.a.

Protein Preferred Names

Protein Names

N-alpha-acetyltransferase 20

N-acetyltransferase 3 homolog

NAA20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NAA20	P61599	NAA25	Homo sapiens	Q14CX7	Anti Bait CoIP	18570629
Intra	NAA20	P61599	NAA25	Homo sapiens	Q14CX7	Anti Tag CoIP	18570629

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 73

MRT73

Autosomal Recessive Intellectual Developmental Disorder 73

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

Syndromic Microphthalmia

Microphthalmia, Syndromic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08988	NAA20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAA20	VGNC	VGNC:82879
Rattus norvegicus	NAA20	RGD	RGD:1307713
Macaca mulatta	NAA20	VGNC	VGNC:84533
Canis familiaris	NAA20	VGNC	VGNC:54751
Bos taurus	NAA20	VGNC	VGNC:57011
Mus musculus	NAA20	MGD	MGI:1915127

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