2. Gene
  3. EGFL7 - EGF like domain multiple 7 Gene

EGFL7 - EGF like domain multiple 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NEU1; ZNEU1; VE-STATIN

Gene ID: 51162 | Gene type: protein coding

About EGFL7

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,658,856-136,672,678 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 5 paralogues. Broad expression in placenta (RPKM 22.8), fat (RPKM 14.4) and 19 other tissues.

Summary

This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

EGFL7 Products(2)

mRNA Protein Name
NM_016215.5 NP_057299.1 epidermal growth factor-like protein 7 precursor
NM_201446.3 NP_958854.1 epidermal growth factor-like protein 7 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21653829 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
20947685 GOA
acts upstream of or within positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20947685 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EGFL7 Protein Structure

EMI

EMI: EMI domain (27 - 95)

EGF_2

EGF_2: EGF-like domain (107 - 134)

EGF_CA

EGF_CA: Calcium-binding EGF domain (137 - 176)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

epidermal growth factor-like protein 7

EGF-like protein 7

Recombinant EGFL7 Proteins

Cat. No. Product Name Accession Purity
HY-P75730 EGFL7/VE-Statin Protein, Human (sf9, His) Q9UHF1 (Y24-S273) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99215 Parsatuzumab Modulator 96.52% Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04206 EGFL7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EGFL7 RGD RGD:708507
Macaca mulatta EGFL7 VGNC VGNC:72079
Felis catus EGFL7 VGNC VGNC:97412
Canis familiaris EGFL7 VGNC VGNC:40237
Bos taurus EGFL7 VGNC VGNC:59214
Mus musculus EGFL7 MGD MGI:2449923
Others EGFL7 NCBI