DCTN4 - dynactin subunit 4 Gene

Homo sapiens

Also known as P62; DYN4

Gene ID: 51164 | Gene type: protein coding

About DCTN4

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,708,440-150,759,017 (from NCBI)

This gene has 15 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 24.6), bone marrow (RPKM 19.3) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]

DCTN4 Products(3)

mRNA	Protein	Name
NM_001135643.2	NP_001129115.1	dynactin subunit 4 isoform a
NM_001135644.2	NP_001129116.1	dynactin subunit 4 isoform c
NM_016221.4	NP_057305.1	dynactin subunit 4 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16554302	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCTN4 Protein Structure

Dynactin_p62

0
100
200
300
400
460 a.a.

Protein Preferred Names

Protein Names

dynactin subunit 4

dynactin 4 (p62)

DCTN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCTN4	Q9UJW0	ACTR10	Homo sapiens	Q9NZ32	Y2H Array	32296183
Intra	DCTN4	Q9UJW0	ACTR10	Homo sapiens	Q9NZ32	Y2H Prey Pooling	32296183
Intra	DCTN4	Q9UJW0	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	DCTN4	Q9UJW0	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	DCTN4	Q9UJW0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	26871637
Intra	DCTN4	Q9UJW0	GOLGA2	Homo sapiens	Q08379	Validated Y2H	26871637
Intra	DCTN4	Q9UJW0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	DCTN4	Q9UJW0	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	DCTN4	Q9UJW0	GOLGA2	Homo sapiens	Q08379	Y2H Array	26871637
Intra	DCTN4	Q9UJW0	GOLGA2	Homo sapiens	Q08379	Y2H	21516116
Intra	DCTN4	Q9UJW0	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	DCTN4	Q9UJW0	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	DCTN4	Q9UJW0	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	DCTN4	Q9UJW0	MTUS2	Homo sapiens	Q5JR59	Y2H	21516116
Intra	DCTN4	Q9UJW0	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Autosomal Dominant Nonsyndromic Deafness 77

Dfna77

Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03595	DCTN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DCTN4	VGNC	VGNC:71625
Felis catus	DCTN4	VGNC	VGNC:61380
Mus musculus	DCTN4	MGD	MGI:1914915
Bos taurus	DCTN4	VGNC	VGNC:27931
Canis familiaris	DCTN4	VGNC	VGNC:39819
Rattus norvegicus	DCTN4	RGD	RGD:71023

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