HSPA14 - heat shock protein family A (Hsp70) member 14 Gene

Homo sapiens

Also known as HSP70-4; HSP70L1; MSANTD7

Gene ID: 51182 | Gene type: protein coding

About HSPA14

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,838,306-14,871,741 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in cytosol. Colocalizes with ribosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA14 Products(1)

mRNA	Protein	Name
NM_016299.4	NP_057383.2	heat shock 70 kDa protein 14

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16002468	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	16002468	GOA
colocalizes with ribosome	IDA IDA: Inferred from direct assay	16002468	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA14 Protein Structure

HSP70

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 14

HSP70-like protein 1

Related Diseases

Diseases

Alias

Autoimmune Atherosclerosis

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06423	HSPA14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSPA14	MGD	MGI:1354164
Felis catus	HSPA14	VGNC	VGNC:84034
Rattus norvegicus	HSPA14	RGD	RGD:1303296
Macaca mulatta	HSPA14	VGNC	VGNC:106060
Canis familiaris	HSPA14	VGNC	VGNC:52137

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