DNAJC2 - DnaJ heat shock protein family (Hsp40) member C2 Gene

Homo sapiens

Also known as ZRF1; ZUO1; MPP11; MPHOSPH11

Gene ID: 27000 | Gene type: protein coding

About DNAJC2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,312,289-103,344,767 (from NCBI)

This gene has 11 transcripts (splice variants), 231 orthologues and 20 paralogues. Ubiquitous expression in bone marrow (RPKM 19.0), testis (RPKM 17.8) and 25 other tissues.

Summary

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

DNAJC2 Products(4)

mRNA	Protein	Name
NM_001129887.3	NP_001123359.1	dnaJ homolog subfamily C member 2 isoform 2
NM_001362667.2	NP_001349596.1	dnaJ homolog subfamily C member 2 isoform 3
NM_001362668.2	NP_001349597.1	dnaJ homolog subfamily C member 2 isoform 4
NM_014377.3	NP_055192.1	dnaJ homolog subfamily C member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	16002468	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	21179169	GOA
enables histone binding	IDA IDA: Inferred from direct assay	21179169	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21179169	GOA
enables ubiquitin-modified histone reader activity	IDA IDA: Inferred from direct assay	21179169	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21179169	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8885239	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16002468	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	28416769	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8885239	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC2 Protein Structure

DnaJ

Myb_DNA-binding

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily C member 2

DnaJ (Hsp40) homolog, subfamily C, member 2

DNAJC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJC2	Q99543	HSPA14	Homo sapiens	Q0VDF9	Anti Tag CoIP	33961781
Intra	DNAJC2	Q99543	HSPA14	Homo sapiens	Q0VDF9	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03881	DNAJC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAJC2	VGNC	VGNC:78443
Bos taurus	DNAJC2	VGNC	VGNC:53636
Rattus norvegicus	DNAJC2	RGD	RGD:620524
Mus musculus	DNAJC2	MGD	MGI:99470
Canis familiaris	DNAJC2	VGNC	VGNC:51863
Macaca mulatta	DNAJC2	VGNC	VGNC:81305
Others	DNAJC2	NCBI

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