ZNF219 - zinc finger protein 219 Gene

Homo sapiens

Also known as ZFP219

Gene ID: 51222 | Gene type: protein coding

About ZNF219

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,090,077-21,104,722 (from NCBI)

This gene has 13 transcripts (splice variants), 158 orthologues and 14 paralogues. Ubiquitous expression in fat (RPKM 12.4), colon (RPKM 6.8) and 22 other tissues.

Summary

This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]

ZNF219 Products(3)

mRNA	Protein	Name
NM_001101672.2	NP_001095142.1	zinc finger protein 219
NM_001102454.2	NP_001095924.1	zinc finger protein 219
NM_016423.3	NP_057507.2	zinc finger protein 219

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14621294	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14621294	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14621294	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14621294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19549071	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14621294	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14621294	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19549071	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10819330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF219 Protein Structure

zf-C2H2

zf-C2H2_4

zf-H2C2_5

zf-C2H2

zf-H2C2_2

zf-H2C2_5

0
200
400
600
722 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 219

ZNF219 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF219	Q9P2Y4	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	ZNF219	Q9P2Y4	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Intra	ZNF219	Q9P2Y4	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	ZNF219	Q9P2Y4	LMO1	Homo sapiens	P25800	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Frontonasal Dysplasia 1

Frontorhiny	Frontonasal Dysplasia
Fnd	Frontonasal Malformation
Fnm	Median Facial Cleft Syndrome
Midline Facial Cleft	FND1
Median Cleft Face Syndrome	Median Cleft Syndrome
Frontonasal Dysplasia Sequence	Median Facial Cleft
Tessier Number 0-14 And 30 Facial Cleft	Alx3-Related Frontonasal Dysplasia
Frontonasal Dysplasia Type 1	Isolated Median Cleft Face Syndrome
Doid:0081044	Doid:0081045
Dysplasia, Frontonasal, Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16111	ZNF219 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZNF219	MGD	MGI:1917140
Bos taurus	ZNF219	VGNC	VGNC:37229
Macaca mulatta	ZNF219	VGNC	VGNC:78876
Rattus norvegicus	ZNF219	RGD	RGD:1359259
Canis familiaris	ZNF219	VGNC	VGNC:48675
Felis catus	ZNF219	VGNC	VGNC:67279

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