GLTP - glycolipid transfer protein Gene

Homo sapiens

Gene ID: 51228 | Gene type: protein coding

About GLTP

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,850,945-109,880,541 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues and 5 paralogues. Broad expression in esophagus (RPKM 87.8), skin (RPKM 85.1) and 23 other tissues.

Summary

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

GLTP Products(1)

mRNA	Protein	Name
NM_016433.4	NP_057517.1	glycolipid transfer protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycolipid binding	IDA IDA: Inferred from direct assay	15287756	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22078563	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	15901739	GOA
enables lipid transfer activity	IDA IDA: Inferred from direct assay	15901739	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intermembrane lipid transfer	IDA IDA: Inferred from direct assay	15901739	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	15901739	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLTP Protein Structure

GLTP

0
100
209 a.a.

Protein Preferred Names

Protein Names

glycolipid transfer protein

GLTP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GLTP	Q9NZD2	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	GLTP	Q9NZD2	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	GLTP	Q9NZD2	q8cl89_yerpe	Yersinia pestis	Q8CL89	Y2H Pooling	20711500
Intra	GLTP	Q9NZD2	GLTP	Homo sapiens	Q9NZD2	X-Ray Diffraction	22078563
Intra	GLTP	Q9NZD2	ASPSCR1	Homo sapiens	Q9BZE9	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	SHKBP1	Homo sapiens	Q8TBC3	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	AMD1	Homo sapiens	P17707	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	SHKBP1	Homo sapiens	Q8TBC3	Anti Tag CoIP	28514442
Intra	GLTP	Q9NZD2	AMD1	Homo sapiens	P17707	Anti Tag CoIP	28514442
Intra	GLTP	Q9NZD2	ASPSCR1	Homo sapiens	Q9BZE9-2	Anti Tag CoIP	28514442
Intra	GLTP	Q9NZD2	STARD7	Homo sapiens	Q9NQZ5	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	GLTP	Homo sapiens	Q9NZD2	DLS	22078563
Intra	GLTP	Q9NZD2	STARD7	Homo sapiens	Q9NQZ5	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GLTP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76365	GLTP Protein, Human (HEK293, His)	Q9NZD2 (M1-V209)	≥95%

Related Diseases

Diseases

Alias

D-Bifunctional Protein Deficiency

Bifunctional Peroxisomal Enzyme Deficiency	17-Beta-Hydroxysteroid Dehydrogenase Iv Deficiency
Dbp Deficiency	Peroxisomal Bifunctional Enzyme Deficiency
Pbfe Deficiency	Bifunctional Enzyme Deficiency
Pseudo-Zellweger Syndrome	Zellweger-Like Syndrome
DBPD	Protein Deficiency, D-Bifunctional

Spondylocarpotarsal Synostosis Syndrome

SCT	Spondylocarpotarsal Syndrome
Vertebral Fusion With Carpal Coalition	Congenital Scoliosis With Unilateral Unsegmented Bar
Congenital Synspondylism	Spondylocarpotarsal Synostosis
Synspondylism, Congenital	Scoliosis, Congenital, With Unilateral Unsegmented Bar
Scoliosis, Congenital With Unilateral Unsegmented Bar	Synspondylism Congenital
Sct Syndrome	Synspondylism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05506	GLTP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GLTP	VGNC	VGNC:62599
Bos taurus	GLTP	VGNC	VGNC:50097
Mus musculus	GLTP	MGD	MGI:1929253
Macaca mulatta	GLTP	VGNC	VGNC:108345
Rattus norvegicus	GLTP	RGD	RGD:1564442
Others	GLTP	NCBI

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