2. Gene
  3. NT5C3A - 5'-nucleotidase, cytosolic IIIA Gene

NT5C3A - 5'-nucleotidase, cytosolic IIIA Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as p36; PN-I; POMP; PSN1; UMPH; NT5C3; P5N-1; UMPH1; hUMP1; P5'N-1; cN-III

Gene ID: 51251 | Gene type: protein coding

About NT5C3A

Summary

This gene encodes a member of the 5'-nucleotidase family of Enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]

NT5C3A Products(1)

mRNA Protein Name
NM_001356996.3 NP_001343925.1 cytosolic 5'-nucleotidase 3A isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
10942414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
21478870 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8557639 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
8557639 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytosolic 5'-nucleotidase 3A

5'-nucleotidase, cytosolic III

7-methylguanosine phosphate-specific 5'-nucleotidase

cytosolic 5'-nucleotidase 3

lupin

pyrimidine 5'-nucleotidase 1

uridine 5'-monophosphate hydrolase 1

NT5C3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NT5C3A Q9H0P0 DESI1 Homo sapiens Q6ICB0
Y2H Array
32296183
Intra
NT5C3A Q9H0P0 DESI1 Homo sapiens Q6ICB0
Y2H Prey Pooling
32296183
Intra
NT5C3A Q9H0P0 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
NT5C3A Q9H0P0 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
NT5C3A Q9H0P0 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NT5C3A Proteins

Cat. No. Product Name Accession Purity
HY-P77455 NT5C3A/NT5C3 Protein, Human Q9H0P0-1 (M12-L297) ≥95%