1. Gene
  2. DESI1 - desumoylating isopeptidase 1 Gene

DESI1 - desumoylating isopeptidase 1 Gene

Homo sapiens

Also known as POST; DESI2; DeSI-1; PPPDE2; FAM152B; D15Wsu75e; DJ347H13.4

Gene ID: 27351 | Gene type: protein coding

About DESI1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,598,028-41,621,043 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 7.4), esophagus (RPKM 4.9) and 25 other tissues.

Summary

Enables importin-alpha family protein binding activity. Involved in protein export from nucleus and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

DESI1 Products(1)

mRNA Protein Name
NM_015704.3 NP_056519.1 desumoylating isopeptidase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables importin-alpha family protein binding IPI
IPI: Inferred from physical interaction
29666234 GOA
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
35427157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29666234 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein export from nucleus IPI
IPI: Inferred from physical interaction
29666234 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
29666234 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
29666234 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
29666234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DESI1 Protein Structure

Peptidase_C97

Peptidase_C97: PPPDE putative peptidase domain (8 - 146)

  • 0
  • 100
  • 168 a.a.
Protein Preferred Names Protein Names

desumoylating isopeptidase 1

PPPDE peptidase domain containing 2

DESI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DESI1 Q6ICB0 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
DESI1 Q6ICB0 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 CTAG2 Homo sapiens O75638-2
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 CTAG2 Homo sapiens O75638-2
Y2H Array
32296183
Intra
DESI1 Q6ICB0 UBQLNL Homo sapiens Q8IYU4
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 UBQLNL Homo sapiens Q8IYU4
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 UBQLNL Homo sapiens Q8IYU4
Y2H Array
32296183
Intra
DESI1 Q6ICB0 UHRF2 Homo sapiens Q96PU4-2
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 PRR5 Homo sapiens P85299-2
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 PRR5 Homo sapiens P85299-2
Y2H Array
32296183
Intra
DESI1 Q6ICB0 SHISA5 Homo sapiens Q8N114-3
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 SHISA5 Homo sapiens Q8N114-3
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 SHISA5 Homo sapiens Q8N114-3
Y2H Array
32296183
Intra
DESI1 Q6ICB0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
DESI1 Q6ICB0 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
DESI1 Q6ICB0 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
DESI1 Q6ICB0 SHISA4 Homo sapiens Q96DD7
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 SHISA4 Homo sapiens Q96DD7
Y2H Array
32296183
Intra
DESI1 Q6ICB0 SHISA4 Homo sapiens Q96DD7
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 KLRF1 Homo sapiens Q4KN05
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 KLRF1 Homo sapiens Q4KN05
Y2H Array
32296183
Intra
DESI1 Q6ICB0 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
DESI1 Q6ICB0 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 SMIM21 Homo sapiens Q3B7S5
Y2H Array
32296183
Intra
DESI1 Q6ICB0 SMIM21 Homo sapiens Q3B7S5
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 CDIP1 Homo sapiens Q9H305
Y2H Array
32296183
Intra
DESI1 Q6ICB0 CDIP1 Homo sapiens Q9H305
MAPPIT
32296183
Intra
DESI1 Q6ICB0 CDIP1 Homo sapiens Q9H305
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 CDIP1 Homo sapiens Q9H305
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 UBC Homo sapiens P0CG48
Y2H Array
32296183
Intra
DESI1 Q6ICB0 UBA52 Homo sapiens P62987
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 UBA52 Homo sapiens P62987
Y2H Array
32296183
Intra
DESI1 Q6ICB0 RPS27A Homo sapiens P62979
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 RPS27A Homo sapiens P62979
Y2H Array
32296183
Intra
DESI1 Q6ICB0 NT5C3A Homo sapiens Q9H0P0
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 AGR3 Homo sapiens Q8TD06
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
DESI1 Q6ICB0 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 NME3 Homo sapiens Q13232
Y2H Array
32296183
Intra
DESI1 Q6ICB0 NME3 Homo sapiens Q13232
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
DESI1 Q6ICB0 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
DESI1 Q6ICB0 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra
DESI1 Q6ICB0 ERP29 Homo sapiens P30040
Y2H Array
32296183
Intra
DESI1 Q6ICB0 ERP29 Homo sapiens P30040
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
DESI1 Q6ICB0 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
DESI1 Q6ICB0 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pulmonary Aspergilloma
Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7

PARK7

Parkinson'S Disease 7

Autosomal Recessive Early-Onset Parkinson'S Disease 7

Parkinson Disease 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

Autosomal Recessive Early-Onset Parkinson Disease Type 7

Parkinson Disease, Type 7

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta DESI1 VGNC VGNC:71702
Bos taurus DESI1 VGNC VGNC:28014
Mus musculus DESI1 MGD MGI:106313
Rattus norvegicus DESI1 RGD RGD:1305776
Canis familiaris DESI1 VGNC VGNC:39906
Felis catus DESI1 VGNC VGNC:83865