IER5 - immediate early response 5 Gene

Homo sapiens

Also known as SBBI48

Gene ID: 51278 | Gene type: protein coding

About IER5

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:181,088,700-181,092,900 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 2 paralogues.

Summary

This gene encodes a protein that is similar to Other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

IER5 Products(1)

mRNA	Protein	Name
NM_016545.5	NP_057629.2	immediate early response gene 5 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	26496226	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26496226	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25816751	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to heat	IDA IDA: Inferred from direct assay	25816751	GOA
involved in positive regulation of cellular response to heat	IMP IMP: Inferred from mutant phenotype	26496226	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25816751	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	26496226	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25816751	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25816751	GOA
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	25816751	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IER5 Protein Structure

IER

0
100
200
300
327 a.a.

Protein Preferred Names

Protein Names

immediate early response gene 5 protein

IER5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IER5	Q5VY09	MINK1	Homo sapiens	Q8N4C8-4	Pull Down	26496226
Intra	IER5	Q5VY09	PPP2CA	Homo sapiens	P67775	Pull Down	26496226
Intra	IER5	Q5VY09	HSF1	Homo sapiens	Q00613	Pull Down	26496226
Intra	IER5	Q5VY09	IER5	Homo sapiens	Q5VY09	Pull Down	26496226
Intra	IER5	Q5VY09	RPS6KB1	Homo sapiens	P23443	Pull Down	26496226

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06550	IER5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06551	IER5L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IER5	VGNC	VGNC:30040
Macaca mulatta	IER5	VGNC	VGNC:73561
Mus musculus	IER5	MGD	MGI:1337072
Rattus norvegicus	IER5	RGD	RGD:69252
Felis catus	IER5	VGNC	VGNC:107880
Canis familiaris	IER5	VGNC	VGNC:55742

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