BFAR - bifunctional apoptosis regulator Gene

Homo sapiens

Also known as BAR; RNF47

Gene ID: 51283 | Gene type: protein coding

About BFAR

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:14,632,951-14,669,236 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele and 211 orthologues. Ubiquitous expression in placenta (RPKM 13.9), urinary bladder (RPKM 13.0) and 25 other tissues.

Summary

Enables Caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein Ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Apr 2022]

BFAR Products(2)

mRNA	Protein	Name
NM_001330500.2	NP_001317429.1	bifunctional apoptosis regulator isoform 2
NM_016561.3	NP_057645.1	bifunctional apoptosis regulator isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables caspase binding	IDA IDA: Inferred from direct assay	10716992	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21068390	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	10716992	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21068390	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of IRE1-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	21068390	GOA
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10716992	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21068390	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	21068390	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	21068390	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	21068390	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	21068390	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21068390	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21068390	GOA
located in membrane	IDA IDA: Inferred from direct assay	10716992	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BFAR Protein Structure

zf-C3HC4_4

SAM_1

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

bifunctional apoptosis regulator

RING finger protein 47

Related Diseases

Diseases

Alias

Epulis

Epulides	Gingival Polyp
Polyp Of Gum

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01485	BFAR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BFAR	VGNC	VGNC:70339
Felis catus	BFAR	VGNC	VGNC:60106
Bos taurus	BFAR	VGNC	VGNC:26477
Mus musculus	BFAR	MGD	MGI:1914368
Canis familiaris	BFAR	VGNC	VGNC:38439
Rattus norvegicus	BFAR	RGD	RGD:1304791

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