PDCD2 - programmed cell death 2 Gene

Homo sapiens

Also known as RP8; ZMYND7

Gene ID: 5134 | Gene type: protein coding

About PDCD2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:170,575,295-170,584,637 (from NCBI)

This gene has 15 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates Apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

PDCD2 Products(7)

mRNA	Protein	Name
NM_001199461.2	NP_001186390.1	programmed cell death protein 2 isoform 3
NM_001199462.2	NP_001186391.1	programmed cell death protein 2 isoform 4
NM_001199463.2	NP_001186392.1	programmed cell death protein 2 isoform 5
NM_001199464.2	NP_001186393.1	programmed cell death protein 2 isoform 6
NM_001363655.2	NP_001350584.1	programmed cell death protein 2 isoform 7
NM_002598.4	NP_002589.2	programmed cell death protein 2 isoform 1
NM_144781.3	NP_659005.1	programmed cell death protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19146857	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	20605493	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	20605493	GOA
involved in positive regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	22922207	GOA
involved in regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	22922207	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD2 Protein Structure

zf-MYND

PDCD2_C

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

programmed cell death protein 2

zinc finger MYND domain-containing protein 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10191	PDCD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDCD2	MGD	MGI:104643
Macaca mulatta	PDCD2	VGNC	VGNC:104419
Felis catus	PDCD2	VGNC	VGNC:97548
Rattus norvegicus	PDCD2	RGD	RGD:61887
Bos taurus	PDCD2	VGNC	VGNC:32660
Canis familiaris	PDCD2	VGNC	VGNC:44337

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