LCMT1 - leucine carboxyl methyltransferase 1 Gene

Homo sapiens

Also known as LCMT; PPMT1; CGI-68

Gene ID: 51451 | Gene type: protein coding

About LCMT1

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:25,111,742-25,178,228 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 19.0), brain (RPKM 15.0) and 25 other tissues.

Summary

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]

LCMT1 Products(2)

mRNA	Protein	Name
NM_001032391.2	NP_001027563.1	leucine carboxyl methyltransferase 1 isoform b
NM_016309.3	NP_057393.2	leucine carboxyl methyltransferase 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein C-terminal carboxyl O-methyltransferase activity	IDA IDA: Inferred from direct assay	10600115	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within C-terminal protein methylation	IDA IDA: Inferred from direct assay	10600115	GOA
acts upstream of or within negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	17724024	GOA
acts upstream of or within protein methylation	IMP IMP: Inferred from mutant phenotype	17724024	GOA
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17724024	GOA
acts upstream of or within regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	17724024	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCMT1 Protein Structure

LCM

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

leucine carboxyl methyltransferase 1

[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

LCMT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LCMT1	Q9UIC8	FXR2	Homo sapiens	P51116	Pull Down	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY	Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency
Hypermethioninemia Due To Gnmt Deficiency	Hypermethioninemia
Hepatic Methionine Adenosyltransferase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07552	LCMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LCMT1	RGD	RGD:735118
Canis familiaris	LCMT1	VGNC	VGNC:42609
Mus musculus	LCMT1	MGD	MGI:1353593
Bos taurus	LCMT1	VGNC	VGNC:30812
Macaca mulatta	LCMT1	VGNC	VGNC:74067

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