2. Gene
  3. FXR2 - FMR1 autosomal homolog 2 Gene

FXR2 - FMR1 autosomal homolog 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FXR2P; FMR1L2

Gene ID: 9513 | Gene type: protein coding

About FXR2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,591,230-7,614,897 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 19.4), testis (RPKM 17.3) and 25 other tissues.

Summary

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]

FXR2 Products(1)

mRNA Protein Name
NM_004860.4 NP_004851.2 RNA-binding protein FXR2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7489725 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
7489725 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
7489725 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7489725 GOA
is active in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
12417522 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FXR2 Protein Structure

Agenet

Agenet: Agenet domain (69 - 128)

KH_1

KH_1: KH domain (231 - 288)

KH_1

KH_1: KH domain (295 - 361)

FXMRP1_C_core

FXMRP1_C_core: Fragile X-related 1 protein core C terminal (371 - 527)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

RNA-binding protein FXR2

fragile X mental retardation syndrome-related protein 2

FXR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra FXR2 P51116 HMBOX1 Homo sapiens Q6NT76-2
Y2H Prey Pooling
25416956
Intra FXR2 P51116 HMBOX1 Homo sapiens Q6NT76-2
Validated Y2H
25416956
Intra FXR2 P51116 FMR1 Homo sapiens Q06787-8
Validated Y2H
25416956
Intra FXR2 P51116 INPP5J Homo sapiens Q15735
Validated Y2H
32296183
Intra FXR2 P51116 MIA3 Homo sapiens Q5JRA6-2
Y2H Prey Pooling
25416956
Intra FXR2 P51116 SYT6 Homo sapiens Q5T7P8-2
Y2H Prey Pooling
25416956
Intra FXR2 P51116 SYT6 Homo sapiens Q5T7P8-2
Y2H Array
25416956
Intra FXR2 P51116 SYT6 Homo sapiens Q5T7P8-2
Validated Y2H
25416956
Intra FXR2 P51116 SYT6 Homo sapiens Q5T7P8-2
Validated Y2H
32296183
Intra FXR2 P51116 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra FXR2 P51116 BAZ2B Homo sapiens Q9UIF8-2
Y2H Prey Pooling
25416956
Intra FXR2 P51116 MRPL43 Homo sapiens Q8N983
Y2H Array
25416956
Intra FXR2 P51116 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra FXR2 P51116 MFAP1 Homo sapiens P55081
Validated Y2H
32296183
Intra FXR2 P51116 NEXN Homo sapiens Q0ZGT2-4
Validated Y2H
32296183
Intra FXR2 P51116 IGFN1 Homo sapiens Q86VF2-5
Validated Y2H
32296183
Intra FXR2 P51116 FMR1 Homo sapiens Q8IXW7
Validated Y2H
32296183
Intra FXR2 P51116 EIF4G1 Homo sapiens Q04637-9
Validated Y2H
32296183
Intra FXR2 P51116 BLK Homo sapiens P51451
Validated Y2H
32296183
Cross FXR2 P51116 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Y2H Array
36217030
Intra FXR2 P51116 HMBOX1 Homo sapiens Q6NT76
Y2H Array
25416956
Intra FXR2 P51116 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra FXR2 P51116 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra FXR2 P51116 PAF1 Homo sapiens Q8N7H5
Y2H Array
25416956
Intra FXR2 P51116 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
25416956
Intra FXR2 P51116 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
Intra FXR2 P51116 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
32296183
Intra FXR2 P51116 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra FXR2 P51116 PRAM1 Homo sapiens Q96QH2
Y2H Prey Pooling
25416956
Intra FXR2 P51116 PRAM1 Homo sapiens Q96QH2
Validated Y2H
25416956
Intra FXR2 P51116 PRAM1 Homo sapiens Q96QH2
Validated Y2H
32296183
Intra FXR2 P51116 LCP2 Homo sapiens Q13094
Validated Y2H
32296183
Intra FXR2 P51116 LCP2 Homo sapiens Q13094
Y2H Array
25416956
Intra FXR2 P51116 UBAP2L Homo sapiens Q14157
Validated Y2H
32296183
Intra FXR2 P51116 MCRS1 Homo sapiens Q96EZ8
Y2H Pooling
16189514
Intra FXR2 P51116 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra FXR2 P51116 CAMK2D Homo sapiens Q13557
Y2H Array
25416956
Intra FXR2 P51116 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra FXR2 P51116 BYSL Homo sapiens Q13895
Validated Y2H
32296183
Intra FXR2 P51116 FMR1 Homo sapiens Q06787
Y2H Pooling
21653829
Intra FXR2 P51116 FMR1 Homo sapiens Q06787
Anti Tag CoIP
33961781
Intra FXR2 P51116 FMR1 Homo sapiens Q06787
TAP
24981860
Intra FXR2 P51116 CDKL3 Homo sapiens Q8IVW4
Validated Y2H
32296183
Intra FXR2 P51116 CDKL3 Homo sapiens Q8IVW4
Y2H Array
25416956
Intra FXR2 P51116 MORF4L1 Homo sapiens Q9UBU8
Validated Y2H
25416956
Intra FXR2 P51116 MEAF6 Homo sapiens Q9HAF1
Y2H Array
19060904
Intra FXR2 P51116 MEAF6 Homo sapiens Q9HAF1
Y2H Pooling
19060904
Intra FXR2 P51116 MEAF6 Homo sapiens Q9HAF1
Y2H Pooling
16189514
Intra FXR2 P51116 AP1M1 Homo sapiens Q9BXS5
Y2H Prey Pooling
25416956
Intra FXR2 P51116 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra FXR2 P51116 AP1M1 Homo sapiens Q9BXS5
Y2H Array
25416956
Intra FXR2 P51116 CWF19L2 Homo sapiens Q2TBE0
Validated Y2H
32296183
Intra FXR2 P51116 SRPK2 Homo sapiens P78362
Y2H Prey Pooling
25416956
Intra FXR2 P51116 SRPK2 Homo sapiens P78362
Validated Y2H
25416956
Intra FXR2 P51116 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
Intra FXR2 P51116 FAM90A1 Homo sapiens Q86YD7
Y2H Prey Pooling
25416956
Intra FXR2 P51116 PIM1 Homo sapiens P11309
Y2H Prey Pooling
25416956
Intra FXR2 P51116 PAICS Homo sapiens P22234
Y2H Pooling
16189514
Intra FXR2 P51116 PAICS Homo sapiens P22234
Y2H Array
19060904
Intra FXR2 P51116 PAICS Homo sapiens P22234
Y2H Pooling
19060904
Intra FXR2 P51116 PTS Homo sapiens Q03393
Y2H Array
31515488
Intra FXR2 P51116 RABAC1 Homo sapiens Q9UI14
Y2H Pooling
16189514
Intra FXR2 P51116 FBP1 Homo sapiens P09467
Y2H Array
31515488
Intra FXR2 P51116 FXR1 Homo sapiens P51114
Y2H Pooling
21653829
Intra FXR2 P51116 FXR1 Homo sapiens P51114
Anti Tag CoIP
33961781
Intra FXR2 P51116 FXR1 Homo sapiens P51114
Anti Tag CoIP
28514442
Intra FXR2 P51116 ARL6IP1 Homo sapiens Q15041
Y2H Pooling
16189514
Intra FXR2 P51116 ARL6IP1 Homo sapiens Q15041
Y2H Array
19060904
Intra FXR2 P51116 ARL6IP1 Homo sapiens Q15041
Y2H Pooling
19060904
Intra FXR2 P51116 ZBTB22 Homo sapiens O15209
Validated Y2H
25416956
Intra FXR2 P51116 ZBTB22 Homo sapiens O15209
Y2H Array
25416956
Intra FXR2 P51116 POM121 Homo sapiens Q96HA1
Y2H Array
25416956
Intra FXR2 P51116 POM121 Homo sapiens Q96HA1
Y2H
21516116
Intra FXR2 P51116 POM121 Homo sapiens Q96HA1
Y2H Prey Pooling
25416956
Intra FXR2 P51116 CBS Homo sapiens P35520
Y2H Array
31515488
Intra FXR2 P51116 PCBD1 Homo sapiens P61457
Y2H Array
25416956
Intra FXR2 P51116 LDOC1 Homo sapiens O95751
Y2H Pooling
16189514
Intra FXR2 P51116 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
Intra FXR2 P51116 NME1 Homo sapiens P15531
Y2H Array
31515488
Intra FXR2 P51116 MBIP Homo sapiens Q9NS73
Y2H Array
19060904
Intra FXR2 P51116 MBIP Homo sapiens Q9NS73
Y2H Pooling
16189514
Intra FXR2 P51116 MBIP Homo sapiens Q9NS73
Y2H Pooling
19060904
Intra FXR2 P51116 NT5C2 Homo sapiens P49902
Y2H Pooling
16189514
Intra FXR2 P51116 MMTAG2 Homo sapiens Q9BU76
Validated Y2H
25416956
Intra FXR2 P51116 MMTAG2 Homo sapiens Q9BU76
Validated Y2H
32296183
Intra FXR2 P51116 LASP1 Homo sapiens Q14847
Y2H Prey Pooling
25416956
Intra FXR2 P51116 LASP1 Homo sapiens Q14847
Validated Y2H
25416956
Intra FXR2 P51116 LASP1 Homo sapiens Q14847
Y2H Array
25416956
Intra FXR2 P51116 C10orf62 Homo sapiens Q5T681
Y2H Prey Pooling
25416956
Intra FXR2 P51116 C10orf62 Homo sapiens Q5T681
Y2H Pooling
16189514
Intra FXR2 P51116 SYTL4 Homo sapiens Q96C24
Validated Y2H
32296183
Intra FXR2 P51116 SYTL4 Homo sapiens Q96C24
Y2H Array
25416956
Intra FXR2 P51116 SYTL4 Homo sapiens Q96C24
Y2H Prey Pooling
25416956
Intra FXR2 P51116 SYTL4 Homo sapiens Q96C24
Validated Y2H
25416956
Intra FXR2 P51116 LCMT1 Homo sapiens Q9UIC8
Y2H Pooling
16189514
Intra FXR2 P51116 CEP55 Homo sapiens Q53EZ4
Validated Y2H
25416956
Intra FXR2 P51116 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra FXR2 P51116 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32296183
Intra FXR2 P51116 SCEL Homo sapiens O95171
Y2H Prey Pooling
25416956
Intra FXR2 P51116 TBC1D22B Homo sapiens Q9NU19
Y2H Prey Pooling
25416956
Intra FXR2 P51116 TBC1D22B Homo sapiens Q9NU19
Y2H Array
29892012
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Premature Ovarian Failure 1

Ovarian Failure, Premature

Fmr1-Related Primary Ovarian Insufficiency

Fragile X-Associated Primary Ovarian Insufficiency

POF1

Pofx

Hypergonadotropic Ovarian Failure, X-Linked

Pof

Primary Ovarian Insufficiency, Fragile X-Associated

Primary Ovarian Insufficiency 1

Ovarian Failure Premature

Premature Ovarian Failure, X-Linked

Fragile X Premature Ovarian Failure

Fmr1-Related Premature Ovarian Failure

Familial Premature Ovarian Failure

Idiopathic Familial Premature Ovarian Failure

Fxpoi

X-Linked Hypergonadotropic Ovarian Failure

Hypergonadotropic Ovarian Failure X-Linked

Poi

Premature Ovarian Failure X-Linked

Primary Ovarian Insufficiency

Premature Ovarian Failure-1

Ovarian Failure, Premature, Type 1

Premature Ovarian Failure, Familial

Premature Menopause

Primary Hypogonadism

Turner Syndrome
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05164 FXR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FXR2 RGD RGD:1307011
Bos taurus FXR2 VGNC VGNC:55832
Mus musculus FXR2 MGD MGI:1346074
Macaca mulatta FXR2 VGNC VGNC:99153
Canis familiaris FXR2 VGNC VGNC:53386
Felis catus FXR2 VGNC VGNC:99059