EVL - Enah/Vasp-like Gene

Homo sapiens

Also known as RNB6

Gene ID: 51466 | Gene type: protein coding

About EVL

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,971,422-100,144,236 (from NCBI)

This gene has 24 transcripts (splice variants), 264 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 31.5), spleen (RPKM 27.6) and 24 other tissues.

Summary

Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

EVL Products(2)

mRNA	Protein	Name
NM_001330221.2	NP_001317150.1	ena/VASP-like protein isoform 2
NM_016337.3	NP_057421.1	ena/VASP-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10993894	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in negative regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	23153535	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EVL Protein Structure

WH1

VASP_tetra

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

ena/VASP-like protein

ena/vasodilator-stimulated phosphoprotein-like

EVL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EVL	Q9UI08	SPTAN1	Homo sapiens	Q13813	Anti Tag CoIP	16336193
Intra	EVL	Q9UI08	SPTAN1	Homo sapiens	Q13813	Y2H	16336193
Intra	EVL	Q9UI08	TRIM9	Homo sapiens	Q9C026	Validated Y2H	25416956
Intra	EVL	Q9UI08	ABI3	Homo sapiens	Q9P2A4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gastrointestinal Adenoma

Gi Adenoma

Digestive System Adenoma

Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10	CMS10
Lgm	Myasthenia, Limb-Girdle, Familial
Myasthenia, Limb-Girdle, Familial, Formerly	Lgm, Formerly
Congenital Myasthenic Syndrome Type Ib, Formerly	Cms1b, Formerly
Cms Ib, Formerly	Myasthenic Myopathy, Formerly
Familial Limb-Girdle Myasthenia	Cms1b
Cms Ib	Congenital Myasthenic Syndrome Type 1b
Congenital Myasthenic Syndrome Type Ib	Myasthenic Myopathy
Myasthenic Syndrome, Congenital, Type 10	Congenital Myasthenic Syndrome Ib
Myopathy In Myasthenia Gravis

Drug-Induced Lupus Erythematosus

Dile	Dil
Drug-Induced Systemic Lupus Erythematosus

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04577	EVL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EVL	RGD	RGD:621150
Bos taurus	EVL	VGNC	VGNC:28636
Canis familiaris	EVL	VGNC	VGNC:40505
Felis catus	EVL	VGNC	VGNC:61991
Mus musculus	EVL	MGD	MGI:1194884
Macaca mulatta	EVL	VGNC	VGNC:72306
Others	EVL	NCBI

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