LIMA1 - LIM domain and actin binding 1 Gene

Homo sapiens

Also known as EPLIN; LDLCQ8; SREBP3

Gene ID: 51474 | Gene type: protein coding

About LIMA1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,175,788-50,283,520 (from NCBI)

This gene has 16 transcripts (splice variants), 222 orthologues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 57.9), small intestine (RPKM 51.2) and 23 other tissues.

Summary

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some Cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

LIMA1 Products(12)

mRNA	Protein	Name
NM_001113546.2	NP_001107018.1	LIM domain and actin-binding protein 1 isoform 1
NM_001113547.2	NP_001107019.1	LIM domain and actin-binding protein 1 isoform 3
NM_001243775.2	NP_001230704.1	LIM domain and actin-binding protein 1 isoform 4
NM_001394886.1	NP_001381815.1	LIM domain and actin-binding protein 1 isoform 1
NM_001394887.1	NP_001381816.1	LIM domain and actin-binding protein 1 isoform 2
NM_001394888.1	NP_001381817.1	LIM domain and actin-binding protein 1 isoform 2
NM_001394889.1	NP_001381818.1	LIM domain and actin-binding protein 1 isoform 5
NM_001394890.1	NP_001381819.1	LIM domain and actin-binding protein 1 isoform 6
NM_001394891.1	NP_001381820.1	LIM domain and actin-binding protein 1 isoform 7
NM_001394892.1	NP_001381821.1	LIM domain and actin-binding protein 1 isoform 8
NM_001394893.1	NP_001381822.1	LIM domain and actin-binding protein 1 isoform 9
NM_016357.5	NP_057441.1	LIM domain and actin-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	12566430	GOA
enables actin monomer binding	IDA IDA: Inferred from direct assay	12566430	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	12566430	GOA
involved in negative regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	12566430	GOA
involved in ruffle organization	IDA IDA: Inferred from direct assay	12566430	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cleavage furrow	IDA IDA: Inferred from direct assay	20309963	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	10618726	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	10618726	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMA1 Protein Structure

LIM

0
200
400
600
759 a.a.

Protein Preferred Names

Protein Names

LIM domain and actin-binding protein 1

epithelial protein lost in neoplasm beta

LIMA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LIMA1	Q9UHB6	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	LIMA1	Q9UHB6	DAPK1	Homo sapiens	P53355	Protein Array	29513927
Intra	LIMA1	Q9UHB6	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	18093941
Intra	LIMA1	Q9UHB6	CDH1	Homo sapiens	P12830	Anti Bait CoIP	18093941
Cross	LIMA1	Q9UHB6	SVIL	Bos taurus	O46385	Y2H	20309963

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 8

LDLCQ8

Low Density Lipoprotein Cholesterol Level Qtl 8

Retinitis Pigmentosa 54

RP54	Retinitis Pigmentosa, Type 54

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07657	LIMA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LIMA1	RGD	RGD:1564050
Bos taurus	LIMA1	VGNC	VGNC:30886
Mus musculus	LIMA1	MGD	MGI:1920992
Macaca mulatta	LIMA1	VGNC	VGNC:74114
Felis catus	LIMA1	VGNC	VGNC:63228
Canis familiaris	LIMA1	VGNC	VGNC:42677

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