GTSE1 - G2 and S-phase expressed 1 Gene

Homo sapiens

Also known as B99

Gene ID: 51512 | Gene type: protein coding

About GTSE1

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:46,296,870-46,330,810 (from NCBI)

This gene has 4 transcripts (splice variants), 178 orthologues and 1 paralogue. Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues.

Summary

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce Apoptosis. [provided by RefSeq, Jul 2008]

GTSE1 Products(1)

mRNA	Protein	Name
NM_016426.7	NP_057510.5	G2 and S phase-expressed protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20577264	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	10974554	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTSE1 Protein Structure

GTSE1_N

0
200
400
600
739 a.a.

Protein Preferred Names

Protein Names

G2 and S phase-expressed protein 1

G-2 and S-phase expressed 1

GTSE1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GTSE1	Q9NYZ3	PLK1	Homo sapiens	P53350	Protein Kinase Assay	20577264
Intra	GTSE1	Q9NYZ3	PLK1	Homo sapiens	P53350	Anti Bait CoIP	20577264

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration

Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type	Amcn
Arthrogryposis Multiplex Congenita Neurogenic Type	AMC2
Amc, Neurogenic Type	Neurogenic-Type Arthrogryposis Multiplex Congenita-2
Amc Neurogenic Type	Neurogenic Type Of Amc
Neurogenic Arthrogryposis Multiplex Congenita	Arthrogryposis Multiplex Congenita, Neurogenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162808	GTSE1-IN-1		97.02%	Unkown
HY-RS05913	GTSE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GTSE1	RGD	RGD:1563164
Canis familiaris	GTSE1	VGNC	VGNC:41559
Bos taurus	GTSE1	VGNC	VGNC:29711
Macaca mulatta	GTSE1	VGNC	VGNC:73162
Mus musculus	GTSE1	MGD	MGI:1352755
Felis catus	GTSE1	VGNC	VGNC:62738

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