ANAPC11 - anaphase promoting complex subunit 11 Gene

Homo sapiens

Also known as APC11; Apc11p; HSPC214

Gene ID: 51529 | Gene type: protein coding

About ANAPC11

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,890,790-81,900,533 (from NCBI)

This gene has 23 transcripts (splice variants), 166 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues.

Summary

Enables cullin family protein binding activity and ubiquitin-ubiquitin Ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]

ANAPC11 Products(12)

mRNA	Protein	Name
NM_001002244.2	NP_001002244.1	anaphase-promoting complex subunit 11 isoform 1
NM_001002245.2	NP_001002245.1	anaphase-promoting complex subunit 11 isoform 2
NM_001002246.2	NP_001002246.1	anaphase-promoting complex subunit 11 isoform 2
NM_001002247.2	NP_001002247.1	anaphase-promoting complex subunit 11 isoform 2
NM_001002248.3	NP_001002248.1	anaphase-promoting complex subunit 11 isoform 2
NM_001002249.2	NP_001002249.1	anaphase-promoting complex subunit 11 isoform 2
NM_001289414.1	NP_001276343.1	anaphase-promoting complex subunit 11 isoform 2
NM_001289415.1	NP_001276344.1	anaphase-promoting complex subunit 11 isoform 2
NM_001289416.1	NP_001276345.1	anaphase-promoting complex subunit 11 isoform 2
NM_001289417.1	NP_001276346.1	anaphase-promoting complex subunit 11 isoform 2
NM_001289420.1	NP_001276349.1	anaphase-promoting complex subunit 11 isoform 4
NM_016476.11	NP_057560.8	anaphase-promoting complex subunit 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cullin family protein binding	IDA IDA: Inferred from direct assay	10230407	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	10230407	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	11739784	GOA
enables ubiquitin-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	10230407	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in positive regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	11739784	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	11739784	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	11739784	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC11 Protein Structure

zf-ANAPC11

0
84 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit 11

APC11 anaphase promoting complex subunit 11 homolog

ANAPC11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANAPC11	Q9NYG5	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	ANAPC11	Q9NYG5	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	ANAPC11	Q9NYG5	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00679	ANAPC11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANAPC11	VGNC	VGNC:51919
Rattus norvegicus	ANAPC11	RGD	RGD:1561880
Bos taurus	ANAPC11	VGNC	VGNC:55771
Macaca mulatta	ANAPC11	VGNC	VGNC:99115
Mus musculus	ANAPC11	MGD	MGI:1913406

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