PCF11 - PCF11 cleavage and polyadenylation factor subunit Gene

Homo sapiens

Gene ID: 51585 | Gene type: protein coding

About PCF11

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:83,157,131-83,187,451 (from NCBI)

This gene has 8 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in lymph node (RPKM 13.1), spleen (RPKM 12.7) and 25 other tissues.

Summary

The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]

PCF11 Products(4)

mRNA	Protein	Name
NM_001346413.3	NP_001333342.1	pre-mRNA cleavage complex 2 protein Pcf11 isoform 1
NM_001346414.2	NP_001333343.1	pre-mRNA cleavage complex 2 protein Pcf11 isoform 2
NM_001346415.2	NP_001333344.1	pre-mRNA cleavage complex 2 protein Pcf11 isoform 4
NM_015885.4	NP_056969.2	pre-mRNA cleavage complex 2 protein Pcf11 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	29196535	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in termination of RNA polymerase II transcription	IDA IDA: Inferred from direct assay	29196535	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	29196535	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCF11 Protein Structure

CTD_bind

0
300
600
900
1200
1555 a.a.

Protein Preferred Names

Protein Names

pre-mRNA cleavage complex 2 protein Pcf11

PCF11, cleavage and polyadenylation factor subunit, homolog

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10144	PCF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCF11	RGD	RGD:1563397
Bos taurus	PCF11	VGNC	VGNC:32625
Canis familiaris	PCF11	VGNC	VGNC:44299
Mus musculus	PCF11	MGD	MGI:1919579
Macaca mulatta	PCF11	VGNC	VGNC:75701
Felis catus	PCF11	VGNC	VGNC:64065

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