TRIM33 - tripartite motif containing 33 Gene

Homo sapiens

Also known as ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA

Gene ID: 51592 | Gene type: protein coding

About TRIM33

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,392,790-114,511,203 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 80 paralogues and is associated with 80 phenotypes. Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

TRIM33 Products(2)

mRNA	Protein	Name
NM_015906.4	NP_056990.3	E3 ubiquitin-protein ligase TRIM33 isoform alpha
NM_033020.3	NP_148980.2	E3 ubiquitin-protein ligase TRIM33 isoform beta

TRIM33 Protein Structure

zf-RING_2

zf-B_box

PHD

Bromodomain

0
200
400
600
800
1000
1127 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM33

RET-fused gene 7 protein

Related Diseases

Diseases

Alias

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Orbital Plasma Cell Granuloma

Orbital Myositis	Orbital Pseudotumor
Pseudotumor Of Orbit	Plasma Cell Granuloma, Orbital

Renal Pelvis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Kidney Pelvis

Squamous Cell Carcinoma Of Renal Pelvis

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Granulomatous Myositis

Chronic Orbital Inflammation

Chronic Inflammation Of Orbit

Muscle Tissue Disease

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Exanthem

Exanthema	Rash
Rashes

Muscular Disease

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15038	TRIM33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIM33	VGNC	VGNC:107684
Mus musculus	TRIM33	MGD	MGI:2137357
Macaca mulatta	TRIM33	VGNC	VGNC:79028
Bos taurus	TRIM33	VGNC	VGNC:36329
Rattus norvegicus	TRIM33	RGD	RGD:1307339
Canis familiaris	TRIM33	VGNC	VGNC:47815

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