2. Gene
  3. TRIM33 - tripartite motif containing 33 Gene

TRIM33 - tripartite motif containing 33 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA

Gene ID: 51592 | Gene type: protein coding

About TRIM33

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,392,790-114,511,203 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues, 80 paralogues and is associated with 80 phenotypes. Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

TRIM33 Products(2)

mRNA Protein Name
NM_015906.4 NP_056990.3 E3 ubiquitin-protein ligase TRIM33 isoform alpha
NM_033020.3 NP_148980.2 E3 ubiquitin-protein ligase TRIM33 isoform beta
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
19135894 GOA
enables co-SMAD binding IPI
IPI: Inferred from physical interaction
19135894 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19135894 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
19135894 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19135894 GOA
involved in regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
19135894 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
19135894 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM33 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (123 - 185)

zf-B_box

zf-B_box: B-box zinc finger (213 - 256)

zf-B_box

zf-B_box: B-box zinc finger (273 - 310)

PHD

PHD: PHD-finger (889 - 932)

Bromodomain

Bromodomain: Bromodomain (966 - 1049)

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  • 1127 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM33

RET-fused gene 7 protein

TRIM33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIM33 Q9UPN9 SMAD2 Homo sapiens Q15796
Anti Tag CoIP
20603019
Intra
TRIM33 Q9UPN9 SMAD2 Homo sapiens Q15796
Anti Bait CoIP
19135894
Intra
TRIM33 Q9UPN9 SMAD2 Homo sapiens Q15796
Anti Tag CoIP
19135894
Intra
TRIM33 Q9UPN9 TRIM24 Homo sapiens O15164
Anti Tag CoIP
26496610
Intra
TRIM33 Q9UPN9 TRIM24 Homo sapiens O15164
Anti Bait CoIP
21531907
Intra
TRIM33 Q9UPN9 TRIM24 Homo sapiens O15164
Anti Tag CoIP
35271311
Intra
TRIM33 Q9UPN9 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
20603019
Intra
TRIM33 Q9UPN9 SMAD4 Homo sapiens Q13485
Anti Bait CoIP
21597466
Intra
TRIM33 Q9UPN9 SMAD4 Homo sapiens Q13485
Anti Bait CoIP
19135894
Intra
TRIM33 Q9UPN9 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
19135894
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis
Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome
Childhood Type Dermatomyositis

Juvenile Dermatomyositis

Juvenile Dm

Childhood Dermatomyositis

Amyopathic Dermatomyositis

Adm

Dermatomyositis Sine Myositis

Dermatomyositis, Childhood Type
Orbital Plasma Cell Granuloma

Orbital Myositis

Orbital Pseudotumor

Pseudotumor Of Orbit

Plasma Cell Granuloma, Orbital
Renal Pelvis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Kidney Pelvis

Squamous Cell Carcinoma Of Renal Pelvis
Myositis

Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myositis

Iim

Imm

Idiopathic Inflammatory Myopathies

Myopathy, Familial Idiopathic Inflammatory

Inflammatory Disorder Of Muscle

Idiopathic Inflammatory Myopathy, Familial

Inflammatory Myopathy, Idiopathic

Myopathies Idiopathic Inflammatory

Familial Idiopathic Inflammatory Myopathy
Granulomatous Myositis
Chronic Orbital Inflammation

Chronic Inflammation Of Orbit
Muscle Tissue Disease
Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx
Exanthem

Exanthema

Rash

Rashes
Muscular Disease
Myopathy

Muscular Diseases

Myopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15038 TRIM33 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIM33 VGNC VGNC:107684
Mus musculus TRIM33 MGD MGI:2137357
Macaca mulatta TRIM33 VGNC VGNC:79028
Bos taurus TRIM33 VGNC VGNC:36329
Rattus norvegicus TRIM33 RGD RGD:1307339
Canis familiaris TRIM33 VGNC VGNC:47815