TAF9B - TATA-box binding protein associated factor 9b Gene

Homo sapiens

Also known as DN7; DN-7; TAF9L; TAFII31L; TFIID-31

Gene ID: 51616 | Gene type: protein coding

About TAF9B

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:78,129,748-78,139,650 (from NCBI)

This gene has 2 transcripts (splice variants), 93 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 16.6), endometrium (RPKM 13.8) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

TAF9B Products(1)

mRNA	Protein	Name
NM_015975.5	NP_057059.2	transcription initiation factor TFIID subunit 9B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15899866	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12837753	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12837753	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15899866	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	15899866	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	15899866	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	15899866	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF9B Protein Structure

TFIID-31kDa

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 9B

TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Siderius Type

Mrxssd	Siderius-Hamel Syndrome
Siderius X-Linked Mental Retardation Syndrome

Plantar Fasciitis

Fasciitis, Plantar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14178	TAF9B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TAF9B	VGNC	VGNC:65938
Mus musculus	TAF9B	MGD	MGI:3039562
Canis familiaris	TAF9B	VGNC	VGNC:47091
Macaca mulatta	TAF9B	VGNC	VGNC:78150
Rattus norvegicus	TAF9B	RGD	RGD:621116
Bos taurus	TAF9B	VGNC	VGNC:35583

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