1. Gene
  2. DRAP1 - DR1 associated protein 1 Gene

DRAP1 - DR1 associated protein 1 Gene

Homo sapiens

Also known as NC2-alpha

Gene ID: 10589 | Gene type: protein coding

About DRAP1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,919,426-65,921,563 (from NCBI)

This gene has 9 transcripts (splice variants), 189 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 51.3), fat (RPKM 37.1) and 25 other tissues.

Summary

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

DRAP1 Products(1)

mRNA Protein Name
NM_006442.4 NP_006433.2 dr1-associated corepressor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to DNA binding IDA
IDA: Inferred from direct assay
8670811 GOA
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
8670811 GOA
enables RNA polymerase II general transcription initiation factor binding IDA
IDA: Inferred from direct assay
8608938 GOA
enables RNA polymerase II general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
8670811 GOA
enables TBP-class protein binding IPI
IPI: Inferred from physical interaction
8670811 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8670811 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
8670811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRAP1 Protein Structure

CBFD_NFYB_HMF

CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (10 - 74)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

dr1-associated corepressor

negative co-factor 2-alpha

DRAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DRAP1 Q14919 MORF4L1 Homo sapiens Q9UBU8-2 32296183
Intra
DRAP1 Q14919 MCRS1 Homo sapiens Q96EZ8 32296183
Intra
DRAP1 Q14919 GTF2B Homo sapiens Q00403 25416956
Intra
DRAP1 Q14919 GTF2B Homo sapiens Q00403 25416956
Intra
DRAP1 Q14919 NFYB Homo sapiens P25208 25416956
Intra
DRAP1 Q14919 NFYB Homo sapiens P25208 25416956
Intra
DRAP1 Q14919 NFYB Homo sapiens P25208 25416956
Intra
DRAP1 Q14919 TAF9 Homo sapiens Q16594 25416956
Intra
DRAP1 Q14919 TAF9 Homo sapiens Q16594 32296183
Intra
DRAP1 Q14919 NCK2 Homo sapiens O43639 25416956
Intra
DRAP1 Q14919 SDCBP Homo sapiens O00560 27107012
Intra
DRAP1 Q14919 SDCBP Homo sapiens O00560 27107012
Intra
DRAP1 Q14919 LMO2 Homo sapiens P25791 25416956
Intra
DRAP1 Q14919 LMO2 Homo sapiens P25791
Y2H
21516116
Intra
DRAP1 Q14919 LNX1 Homo sapiens Q8TBB1 32296183
Intra
DRAP1 Q14919 POLE3 Homo sapiens Q9NRF9 25416956
Intra
DRAP1 Q14919 POLE3 Homo sapiens Q9NRF9 25416956
Intra
DRAP1 Q14919 POLE3 Homo sapiens Q9NRF9 16189514
Intra
DRAP1 Q14919 POLE3 Homo sapiens Q9NRF9 32296183
Intra
DRAP1 Q14919 TAF9B Homo sapiens Q9HBM6 25416956
Intra
DRAP1 Q14919 TAF9B Homo sapiens Q9HBM6 32296183
Intra
DRAP1 Q14919 TAF9B Homo sapiens Q9HBM6 25416956
Intra
DRAP1 Q14919 TAF9B Homo sapiens Q9HBM6 16189514
Intra
DRAP1 Q14919 PICK1 Homo sapiens Q9NRD5 32296183
Intra
DRAP1 Q14919 PIK3R3 Homo sapiens Q92569 32296183
Intra
DRAP1 Q14919 PIK3R3 Homo sapiens Q92569 31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Renpenning Syndrome 1

Renpenning Syndrome

Golabi-Ito-Hall Syndrome

Mrxs3

Mrxs8

X-Linked Intellectual Disability Due To Pqbp1 Mutations

RENS1

Sutherland-Haan X-Linked Mental Retardation Syndrome

Shs

Mrx55

X-Linked Intellectual Disability, Renpenning Type

Sutherland-Haan Syndrome

Mental Retardation, X-Linked, Renpenning Type

Mental Retardation, X-Linked, With Spastic Diplegia

Mental Retardation, X-Linked, Syndromic 3

Mental Retardation, X-Linked, Syndromic 8

Mental Retardation, X-Linked 55

Syndromic X-Linked Mental Retardation 8

X-Linked Mental Retardation Renpenning Type

X-Linked Mental Retardation With Spastic Diplegia

Sutherland-Haan X-Linked Intellectual Disability Syndrome

X-Linked Intellectual Disability With Spastic Diplegia

Hamel Cerebropalatocardiac Syndrome

Porteous Syndrome

X-Linked Intellectual Deficit Due To Pqbp1 Mutations

X-Linked Intellectual Deficit, Renpenning Type

X-Linked Intellectual Disability, Sutherland-Haan Type

Hamel Cerebro-Palato-Cardiac Syndrome

Renpenning Syndrome, Type 1

Triple-Receptor Negative Breast Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus DRAP1 VGNC VGNC:61621
Mus musculus DRAP1 MGD MGI:1913806
Rattus norvegicus DRAP1 RGD RGD:1308477
Canis familiaris DRAP1 VGNC VGNC:103671
Bos taurus DRAP1 VGNC VGNC:28203
Macaca mulatta DRAP1 VGNC VGNC:71987