IL17D - interleukin 17D Gene

Homo sapiens

Also known as IL-17D

Gene ID: 53342 | Gene type: protein coding

About IL17D

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,701,513-20,723,098 (from NCBI)

This gene has 4 transcripts (splice variants), 163 orthologues and 5 paralogues. Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues.

Summary

The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]

IL17D Products(7)

mRNA	Protein	Name
NM_001385221.1	NP_001372150.1	interleukin-17D isoform a precursor
NM_001385222.1	NP_001372151.1	interleukin-17D isoform b precursor
NM_001385223.1	NP_001372152.1	interleukin-17D isoform c precursor
NM_001385224.1	NP_001372153.1	interleukin-17D isoform c precursor
NM_001385225.1	NP_001372154.1	interleukin-17D isoform d
NM_001386973.1	NP_001373902.1	interleukin-17D isoform e
NM_138284.2	NP_612141.1	interleukin-17D isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	12097364	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12097364	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	12097364	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in inflammatory response	IDA IDA: Inferred from direct assay	12097364	GOA
involved in negative regulation of hemopoiesis	IDA IDA: Inferred from direct assay	12097364	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	12097364	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	12097364	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	12097364	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	12097364	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12097364	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17D Protein Structure

IL17

0
100
202 a.a.

Protein Preferred Names

Protein Names

interleukin-17D

Recombinant IL17D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70587	IL-17D Protein, Human	Q8TAD2 (A18-P202)	≥95%
HY-P700106AF	Animal-Free IL-17D Protein, Human (His)	Q8TAD2 (A18-P202)	≥95%

Related Diseases

Diseases

Alias

Hidradenitis Suppurativa

Acne Inversa	Suppurative Hidradenitis
Acne Inversa, Familial	Apocrinitis
Hidradenitides, Suppurative	Hidradenitis, Suppurative
Suppurative Hidradenitides	Inverse Acne

Psoriasis

Hidradenitis

Hydradenitis

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06700	IL17D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL17D	RGD	RGD:1595926
Mus musculus	IL17D	MGD	MGI:2446510
Bos taurus	IL17D	VGNC	VGNC:30120
Others	IL17D	NCBI

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