2. Gene
  3. ZFYVE1 - zinc finger FYVE-type containing 1 Gene

ZFYVE1 - zinc finger FYVE-type containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172

Gene ID: 53349 | Gene type: protein coding

About ZFYVE1

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,969,445-73,027,106 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 6.4) and 25 other tissues.

Summary

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ZFYVE1 Products(4)

mRNA Protein Name
NM_001281734.2 NP_001268663.1 zinc finger FYVE domain-containing protein 1 isoform 3
NM_001281735.1 NP_001268664.1 zinc finger FYVE domain-containing protein 1 isoform 2
NM_021260.4 NP_067083.1 zinc finger FYVE domain-containing protein 1 isoform 1
NM_178441.2 NP_848535.1 zinc finger FYVE domain-containing protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 1-phosphatidylinositol binding IDA
IDA: Inferred from direct assay
11256955 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
11804589 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
11804589 GOA
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
31293035 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19389623 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
25578879 GOA
involved in lipid droplet formation IMP
IMP: Inferred from mutant phenotype
30970241 GOA
involved in macroautophagy IDA
IDA: Inferred from direct assay
25578879 GOA
involved in positive regulation by host of viral genome replication IDA
IDA: Inferred from direct assay
35551511 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
25876663 GOA
located in Golgi stack IDA
IDA: Inferred from direct assay
11256955 GOA
located in autophagosome IDA
IDA: Inferred from direct assay
22456507 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
11739631 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30970241 GOA
located in extrinsic component of omegasome membrane IDA
IDA: Inferred from direct assay
19898463 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
30970241 GOA
colocalizes with membrane IDA
IDA: Inferred from direct assay
25578879 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
23455425 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25876663 GOA
located in omegasome IDA
IDA: Inferred from direct assay
24954904 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11739631 GOA
located in phagophore assembly site IDA
IDA: Inferred from direct assay
23455425 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE1 Protein Structure

FYVE

FYVE: FYVE zinc finger (594 - 657)

FYVE

FYVE: FYVE zinc finger (711 - 773)

  • 0
  • 200
  • 400
  • 600
  • 777 a.a.
Protein Preferred Names Protein Names

zinc finger FYVE domain-containing protein 1

double FYVE-containing protein 1

ZFYVE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZFYVE1 Q9HBF4 PPP1CA Homo sapiens P62136
Far-WB
19389623
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Argyll Robertson Pupil

Atypical Argyll-Robertson Pupil

Argyll Robertson Phenomenon Or Pupil, Nonsyphilitic

Argyll Robertson Pupil, Atypical
Abnormal Pupillary Function
Pupil Disease

Pupil Disorders

Pupillary Disorder
Diamond-Blackfan Anemia 5

DBA5

Rpl35a-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 5
Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18

RP7

Retinitis Pigmentosa 7, Digenic Form

Retinitis Pigmentosa 7 And Digenic Form

Retinitis Pigmentosa 7, Digenic

LCA18

Retinitis Pigmentosa 7 Digenic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16055 ZFYVE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZFYVE1 VGNC VGNC:78911
Mus musculus ZFYVE1 MGD MGI:3026685
Bos taurus ZFYVE1 VGNC VGNC:37173
Rattus norvegicus ZFYVE1 RGD RGD:1307795
Canis familiaris ZFYVE1 VGNC VGNC:48622
Felis catus ZFYVE1 VGNC VGNC:67237