2. Gene
  3. Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 Gene

Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1

Gene ID: 53945 | Gene type: protein coding

About Slc40a1

Chromosome 1: 45,947,228-45,965,683 reverse strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 211 orthologues and is associated with 65 phenotypes. Broad expression in liver E18 (RPKM 41.3), placenta adult (RPKM 28.4) and 21 other tissues.

Summary

Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane. Acts upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc40a1 Products(1)

mRNA Protein Name
NM_016917.2 NP_058613.2 solute carrier family 40 member 1

Slc40a1 Protein Structure

FPN1

FPN1: pfam06963 (21 - 529)

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  • 570 a.a.
Protein Preferred Names Protein Names

solute carrier family 40 member 1

SLC11A3 iron transporter

duodenal-specific

ferroportin 1

ferroportin1

iron-regulated transporter 1

metal transporter protein 1

metal transporting protein 1

polycythaemia

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3

solute carrier family 39 (iron-regulated transporter), member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13243 SLC40A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13244 Slc40a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13245 SLC40A1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc40a1 NCBI NCBI:30061