Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 Gene

Mus musculus

Also known as MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1

Gene ID: 53945 | Gene type: protein coding

About Slc40a1

Chromosome 1: 45,947,228-45,965,683 reverse strand.GRCm39:CM000994.3

This gene has 8 transcripts (splice variants), 211 orthologues and is associated with 65 phenotypes. Broad expression in liver E18 (RPKM 41.3), placenta adult (RPKM 28.4) and 21 other tissues.

Summary

Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane. Acts upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc40a1 Products(1)

mRNA	Protein	Name
NM_016917.2	NP_058613.2	solute carrier family 40 member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ferrous iron transmembrane transporter activity	IDA IDA: Inferred from direct assay	15514116	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19234114	MGI
enables iron ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10828623	MGI
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	15514116	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19234114	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	15342464	MGI
acts upstream of or within endothelium development	IMP IMP: Inferred from mutant phenotype	15342464	MGI
acts upstream of or within establishment of localization in cell	IGI IGI: Inferred from genetic interaction	21700773	MGI
involved in iron ion export across plasma membrane	IDA IDA: Inferred from direct assay	15514116	MGI
acts upstream of or within iron ion transmembrane transport	IGI IGI: Inferred from genetic interaction	21700773	MGI
acts upstream of or within iron ion transport	IDA IDA: Inferred from direct assay	10828623	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	15888661	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	15342464	MGI
involved in multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	15084469	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15342464	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20530874	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	15342464	MGI
acts upstream of or within spleen trabecula formation	IMP IMP: Inferred from mutant phenotype	15342464	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20530874	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IGI IGI: Inferred from genetic interaction	19252488	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16081696	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	14972659	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc40a1 Protein Structure

FPN1

0
100
200
300
400
500
570 a.a.

Protein Preferred Names

Protein Names

solute carrier family 40 member 1

SLC11A3 iron transporter	duodenal-specific
ferroportin 1	ferroportin1
iron-regulated transporter 1	metal transporter protein 1
metal transporting protein 1	polycythaemia
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3	solute carrier family 39 (iron-regulated transporter), member 1

Slc40a1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc40a1	Q9JHI9	Slc40a1	Mus musculus	Q9JHI9	Anti Tag CoIP	19234114
Intra	Slc40a1	Q9JHI9	Jak2	Mus musculus	Q62120	Anti Bait CoIP	19234114
Intra	Slc40a1	Q9JHI9	Cp	Mus musculus	Q61147	Anti Bait CoIP	20817278

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect Inhibitor	Purity	Phase Phase 1
HY-P990618	LY2928057	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS13243	SLC40A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13244	Slc40a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13245	SLC40A1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases Unkown
HY-P990510	Anti-SLC40A1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc40a1	NCBI	NCBI:30061

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