POLB - DNA polymerase beta Gene

Homo sapiens

Gene ID: 5423 | Gene type: protein coding

About POLB

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,338,494-42,371,808 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 3 paralogues. Broad expression in testis (RPKM 24.2), urinary bladder (RPKM 8.5) and 24 other tissues.

Summary

The protein encoded by this gene is a DNA Polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]

POLB Products(1)

mRNA	Protein	Name
NM_002690.3	NP_002681.1	DNA polymerase beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: Inferred from direct assay	9614142	GOA
enables DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	9207062	GOA
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	9614142	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16600869	GOA
enables lyase activity	IDA IDA: Inferred from direct assay	16600869	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	15725623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9207062	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	21362556	GOA
involved in base-excision repair	IDA IDA: Inferred from direct assay	16600869	GOA
involved in base-excision repair	IMP IMP: Inferred from mutant phenotype	21362556	GOA
NOT involved in nucleotide-excision repair, DNA gap filling	IMP IMP: Inferred from mutant phenotype	20227374	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15725623	GOA
located in microtubule	IDA IDA: Inferred from direct assay	15725623	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19713937	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25378300	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	15725623	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLB Protein Structure

HHH_8

DNA_pol_lambd_f

DNA_pol_B_palm

DNA_pol_B_thumb

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

DNA polymerase beta

DNA pol beta

POLB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Validated Y2H	25910212
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Array	31515488
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Bait-Prey Pool	25910212
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Array	25910212
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Validated Y2H	25416956
Intra	POLB	P06746	TAF1D	Homo sapiens	Q9H5J8	Anti Tag CoIP	15520167
Intra	POLB	P06746	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	33961781
Intra	POLB	P06746	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant POLB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7883	DNA polymerase beta Protein, Human (His)	P06746 (S2-E335)	≥95%

POLB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83633	DNA Polymerase beta Antibody (YA3378)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Werner Syndrome

Werner'S Syndrome	WRN
Adult Progeria	Ws
Adult Premature Ageing Syndrome	Adult Premature Aging Syndrome
Werners Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Rhabdomyosarcoma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10818	POLB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POLB	RGD	RGD:3363
Mus musculus	POLB	MGD	MGI:97740
Felis catus	POLB	VGNC	VGNC:68935
Macaca mulatta	POLB	VGNC	VGNC:104470
Canis familiaris	POLB	VGNC	VGNC:44773
Bos taurus	POLB	VGNC	VGNC:33112
Others	POLB	NCBI

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