Crebbp - CREB binding protein Gene

Rattus norvegicus

Also known as CBP; RTS; RSTS

Gene ID: 54244 | Gene type: protein coding

About Crebbp

Primary_assembly 10: 11,335,953-11,461,888 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 277 orthologues, 2 paralogues and is associated with 50 phenotypes. Biased expression in Thymus (RPKM 165.4), Spleen (RPKM 146.7) and 9 other tissues.

Summary

Enables several functions, including SMAD binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator binding activity. Involved in several processes, including behavioral response to cocaine; long-term memory; and positive regulation of NIK/NF-kappaB signaling. Located in nuclear body. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Crebbp Products(1)

mRNA	Protein	Name
NM_133381.4	NP_596872.3	histone lysine acetyltransferase CREBBP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15598887	RGD
enables SMAD binding	IPI IPI: Inferred from physical interaction	16959941	RGD
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	12477714	RGD
enables peroxisome proliferator activated receptor binding	IDA IDA: Inferred from direct assay	12095700	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16456924	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16959941	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	15598887	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	24555056	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	32206715	RGD
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18496732	RGD
involved in positive regulation of cell adhesion molecule production	IMP IMP: Inferred from mutant phenotype	20926146	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	32206715	RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	20926146	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15598887	RGD
involved in protein modification process	IDA IDA: Inferred from direct assay	15632413	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14567501	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	15950780	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	24338162	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear body	IDA IDA: Inferred from direct assay	15488321	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15632413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Crebbp Protein Structure

zf-TAZ

KIX

PHA03247

COG5076

Bromo_cbp_like

RING_CBP-p300

PHD_CBP_p300

HAT_KAT11

ZZ_CBP

zf-TAZ

Med15

Creb_binding

0
400
800
1200
1600
2000
2454 a.a.

Protein Preferred Names

Protein Names

histone lysine acetyltransferase CREBBP

protein-lysine acetyltransferase CREBBP

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19999A	PF-CBP1 hydrochloride	Inhibitor	99.99%	Unkown
HY-128875	CBP/p300-IN-10	Inhibitor	98.69%	Unkown
HY-RS03156	Crebbp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-135236	OXFBD04	Inhibitor	98.99%	Unkown
HY-114971	CREBBP-IN-1		/	Unkown
HY-116237	CREBBP-IN-9	Inhibitor	/	Unkown
HY-128362	Ep300/CREBBP-IN-8	Inhibitor	/	Unkown
HY-128363	Ep300/CREBBP-IN-2	Inhibitor	/	Unkown
HY-128364	Ep300/CREBBP-IN-3	Inhibitor	/	Unkown
HY-128367	Ep300/CREBBP-IN-4	Inhibitor	/	Unkown
HY-RS03155	CREBBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03157	Crebbp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crebbp	NCBI	NCBI:1387

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