Crk - CRK proto-oncogene, adaptor protein Gene

Rattus norvegicus

Also known as Crko; CrkII

Gene ID: 54245 | Gene type: protein coding

About Crk

Summary

Enables several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to nitric oxide; and response to peptide hormone. Located in membrane raft. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Crk Products(1)

mRNA	Protein	Name
NM_019302.1	NP_062175.1	adapter molecule crk

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	17615370	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	9348226	RGD
enables insulin-like growth factor receptor binding	IPI IPI: Inferred from physical interaction	12837295	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8940134	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12011056	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16187300	RGD
enables protein-macromolecule adaptor activity	IMP IMP: Inferred from mutant phenotype	8901553	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	20623582	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to endothelin	IPI IPI: Inferred from physical interaction	12719447	RGD
involved in cellular response to insulin-like growth factor stimulus	IPI IPI: Inferred from physical interaction	12837295	RGD
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	15128873	RGD
involved in cellular response to nitric oxide	IPI IPI: Inferred from physical interaction	12714323	RGD
involved in cellular response to transforming growth factor beta stimulus	IPI IPI: Inferred from physical interaction	12837295	RGD
involved in negative regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	18835194	RGD
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	12198159	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	12714323	RGD
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	12198159	RGD
involved in regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	12198159	RGD
involved in response to cholecystokinin	IDA IDA: Inferred from direct assay	14622258	RGD
involved in response to hepatocyte growth factor	IPI IPI: Inferred from physical interaction	16187300	RGD
involved in response to hydrogen peroxide	IPI IPI: Inferred from physical interaction	16187300	RGD
involved in response to peptide	IPI IPI: Inferred from physical interaction	14622258	RGD
involved in response to yeast	IEP IEP: Inferred from expression pattern	19958054	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adapter molecule crk

avian sarcoma virus CT10 (v-crk) oncogene homolog	p38
proto-oncogene C-crk	v-crk avian sarcoma virus CT10 oncogene homolog
v-crk sarcoma virus CT10 oncogene homolog

Crk Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Crk	Q63768	PTPN1	Homo sapiens	P18031	Pull Down	12023880

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112622	GSK3186899	Inhibitor	98.61%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112346	RGB-286147		98.60%	Unkown
HY-RS16222	Crk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-143322	CRK12-IN-2	Inhibitor	/	Unkown
HY-145812	CRK12-IN-1	Inhibitor	/	Unkown
HY-RS03184	CRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crk	NCBI	NCBI:1398
Mus musculus	Crk	NCBI	NCBI:12928

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