KCNN2 - Kcnn2 potassium calcium-activated channel subfamily N member 2 Gene

Rattus norvegicus

Also known as SK2; SKCa2; KCa2.2; SKCa 2

Gene ID: 54262 | Gene type: protein coding

About KCNN2

Summary

Enables Calmodulin binding activity and small conductance calcium-activated Potassium Channel activity. Involved in positive regulation of potassium ion transport; potassium ion transport; and regulation of neuronal synaptic plasticity. Located in dendritic spine and neuronal cell body. Is integral component of membrane. Used to study essential tremor. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Apr 2022]

KCNN2 Products(2)

mRNA	Protein	Name
NM_001309404.1	NP_001296333.1	small conductance calcium-activated potassium channel protein 2 isoform 1
NM_019314.2	NP_062187.1	small conductance calcium-activated potassium channel protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	9774106	RGD
enables calmodulin binding	IMP IMP: Inferred from mutant phenotype	18701069	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11323678	RGD
enables small conductance calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	8781233	RGD
enables small conductance calcium-activated potassium channel activity	IMP IMP: Inferred from mutant phenotype	14559917	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	28917524	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	11323678	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	21521760	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	21521760	RGD
located in membrane	IDA IDA: Inferred from direct assay	11323678	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15680700	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

small conductance calcium-activated potassium channel protein 2

potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
small conductance calcium-activated potassium channel protein 2-lik

KCNN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Kcnn2	P70604	Calm1	Rattus norvegicus	P0DP29	X-Ray Diffraction	15130477

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07170	KCNN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	KCNN2	NCBI	NCBI:3781

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