2. Gene
  3. POLR2K - RNA polymerase II, I and III subunit K Gene

POLR2K - RNA polymerase II, I and III subunit K Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RPB12; RPABC4; RPB7.0; hRPB7.0; hsRPB10a; RPB10alpha; ABC10-alpha

Gene ID: 5440 | Gene type: protein coding

About POLR2K

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:100,150,636-100,154,003 (from NCBI)

This gene has 3 transcripts (splice variants) and 138 orthologues. Ubiquitous expression in adrenal (RPKM 36.2), thyroid (RPKM 30.3) and 25 other tissues.

Summary

This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the Other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

POLR2K Products(1)

mRNA Protein Name
NM_005034.4 NP_005025.1 DNA-directed RNA polymerases I, II, and III subunit RPABC4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase I complex IDA
IDA: Inferred from direct assay
34671025 GOA
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
33335104 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2K Protein Structure

DNA_RNApol_7kD

DNA_RNApol_7kD: DNA directed RNA polymerase, 7 kDa subunit (17 - 48)

  • 0
  • 58 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerases I, II, and III subunit RPABC4

DNA directed RNA polymerases I, II, and III 7.0 kda polypeptide

POLR2K Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POLR2K P53803 SH3KBP1 Homo sapiens Q96B97
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10853 POLR2K Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POLR2K MGD MGI:102725
Rattus norvegicus POLR2K RGD RGD:2319895
Bos taurus POLR2K VGNC VGNC:57357