2. Gene
  3. SH3KBP1 - SH3 domain containing kinase binding protein 1 Gene

SH3KBP1 - SH3 domain containing kinase binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSB1; AGMX2; CIN85; GIG10; HSB-1; IMD61; MIG18; CD2BP3

Gene ID: 30011 | Gene type: protein coding

About SH3KBP1

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:19,533,977-19,887,600 (from NCBI)

This gene has 50 transcripts (splice variants), 212 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 19.2), fat (RPKM 15.0) and 24 other tissues.

Summary

This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including Apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

SH3KBP1 Products(13)

mRNA Protein Name
NM_001024666.3 NP_001019837.1 SH3 domain-containing kinase-binding protein 1 isoform b
NM_001184960.2 NP_001171889.1 SH3 domain-containing kinase-binding protein 1 isoform c
NM_001353890.2 NP_001340819.1 SH3 domain-containing kinase-binding protein 1 isoform d
NM_001353891.2 NP_001340820.1 SH3 domain-containing kinase-binding protein 1 isoform e
NM_001353892.2 NP_001340821.1 SH3 domain-containing kinase-binding protein 1 isoform f
NM_001353893.2 NP_001340822.1 SH3 domain-containing kinase-binding protein 1 isoform g
NM_001353894.2 NP_001340823.1 SH3 domain-containing kinase-binding protein 1 isoform h
NM_001353895.2 NP_001340824.1 SH3 domain-containing kinase-binding protein 1 isoform i
NM_001353897.2 NP_001340826.1 SH3 domain-containing kinase-binding protein 1 isoform j
NM_001410756.1 NP_001397685.1 SH3 domain-containing kinase-binding protein 1 isoform k
NM_001410757.1 NP_001397686.1 SH3 domain-containing kinase-binding protein 1 isoform l
NM_001410758.1 NP_001397687.1 SH3 domain-containing kinase-binding protein 1 isoform m
NM_031892.3 NP_114098.1 SH3 domain-containing kinase-binding protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10679202 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in positive regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
29636373 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
21834987 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20221403 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3KBP1 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (6 - 53)

SH3_9

SH3_9: Variant SH3 domain (107 - 153)

SH3_9

SH3_9: Variant SH3 domain (274 - 324)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
Protein Preferred Names Protein Names

SH3 domain-containing kinase-binding protein 1

CD2-binding protein 3

SH3KBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SH3KBP1 Q96B97 GGN Homo sapiens Q86UU5
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 GGN Homo sapiens Q86UU5
Y2H Array
32296183
Intra SH3KBP1 Q96B97 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra SH3KBP1 Q96B97 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra SH3KBP1 Q96B97 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra SH3KBP1 Q96B97 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra SH3KBP1 Q96B97 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra SH3KBP1 Q96B97 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra SH3KBP1 Q96B97 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 ZBTB7B Homo sapiens O15156-2
Y2H Array
32296183
Intra SH3KBP1 Q96B97 ZBTB7B Homo sapiens O15156-2
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra SH3KBP1 Q96B97 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 ANKS1A Homo sapiens Q49AR9
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 ANKS1A Homo sapiens Q49AR9
Y2H Array
32296183
Intra SH3KBP1 Q96B97 DENND2A Homo sapiens Q9ULE3-2
Validated Y2H
32296183
Intra SH3KBP1 Q96B97 DENND2A Homo sapiens Q9ULE3-2
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 DENND2A Homo sapiens Q9ULE3-2
Y2H Array
32296183
Intra SH3KBP1 Q96B97 INPP5D Homo sapiens Q92835
Anti Tag CoIP
15090612
Cross SH3KBP1 Q96B97 Dab2 Mus musculus P98078
Pull Down
14596919
Cross SH3KBP1 Q96B97 Dab2 Mus musculus P98078
Anti Bait CoIP
14596919
Intra SH3KBP1 Q96B97 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra SH3KBP1 Q96B97 CD2AP Homo sapiens Q9Y5K6
Anti Tag CoIP
28514442
Intra SH3KBP1 Q96B97 CD2AP Homo sapiens Q9Y5K6
Anti Tag CoIP
33961781
Intra SH3KBP1 Q96B97 CD2AP Homo sapiens Q9Y5K6
Anti Tag CoIP
31980649
Intra SH3KBP1 Q96B97 SQSTM1 Homo sapiens Q13501
Pull Down
20551902
Intra SH3KBP1 Q96B97 SYNJ2 Homo sapiens O15056
Anti Tag CoIP
31980649
Intra SH3KBP1 Q96B97 SYNJ2 Homo sapiens O15056
Anti Tag CoIP
15090612
Intra SH3KBP1 Q96B97 SYNJ2 Homo sapiens O15056
Anti Tag CoIP
33961781
Intra SH3KBP1 Q96B97 ASAP2 Homo sapiens O43150
Anti Tag CoIP
31980649
Intra SH3KBP1 Q96B97 ASAP2 Homo sapiens O43150
Anti Tag CoIP
33961781
Intra SH3KBP1 Q96B97 UBC Homo sapiens P0CG48
NMR
19111555
Intra SH3KBP1 Q96B97 UBC Homo sapiens P0CG48
Pull Down
18680311
Intra SH3KBP1 Q96B97 UBC Homo sapiens P0CG48
NMR
18680311
Intra SH3KBP1 Q96B97 DNM2 Homo sapiens P50570
Anti Bait CoIP
20711168
Intra SH3KBP1 Q96B97 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
31980649
Intra SH3KBP1 Q96B97 ASAP1 Homo sapiens Q9ULH1
Pull Down
17255943
Intra SH3KBP1 Q96B97 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
33961781
Intra SH3KBP1 Q96B97 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
28514442
Intra SH3KBP1 Q96B97 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra SH3KBP1 Q96B97 CAPZA1 Homo sapiens P52907
Anti Tag CoIP
33961781
Intra SH3KBP1 Q96B97 CAPZA1 Homo sapiens P52907
Anti Tag CoIP
31980649
Intra SH3KBP1 Q96B97 CAPZA1 Homo sapiens P52907
Anti Bait CoIP
23178720
Intra SH3KBP1 Q96B97 CAPZA1 Homo sapiens P52907
Anti Tag CoIP
28514442
Intra SH3KBP1 Q96B97 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra SH3KBP1 Q96B97 POLR2K Homo sapiens P53803
Y2H Array
32296183
Intra SH3KBP1 Q96B97 POLR2K Homo sapiens P53803
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 P4HB Homo sapiens P07237
Validated Y2H
32814053
Intra SH3KBP1 Q96B97 P4HB Homo sapiens P07237
Y2H Array
32814053
Intra SH3KBP1 Q96B97 P4HB Homo sapiens P07237
Y2H Pooling
32814053
Intra SH3KBP1 Q96B97 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra SH3KBP1 Q96B97 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra SH3KBP1 Q96B97 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra SH3KBP1 Q96B97 ARAP3 Homo sapiens Q8WWN8
Anti Tag CoIP
15090612
Intra SH3KBP1 Q96B97 ARAP3 Homo sapiens Q8WWN8
Anti Tag CoIP
31980649
Intra SH3KBP1 Q96B97 MAP3K4 Homo sapiens Q9Y6R4
Pull Down
16256071
Intra SH3KBP1 Q96B97 MAP3K4 Homo sapiens Q9Y6R4
Anti Tag CoIP
16256071
Intra SH3KBP1 Q96B97 MAP3K4 Homo sapiens Q9Y6R4
Anti Bait CoIP
16256071
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
Anti Bait CoIP
11894095
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
Anti Tag CoIP
11894095
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
ITC
19268472
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
NMR
19268472
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
Anti Bait CoIP
14596919
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
Anti Bait CoIP
10679202
Intra SH3KBP1 Q96B97 CBL Homo sapiens P22681
Anti Bait CoIP
15090612
Intra SH3KBP1 Q96B97 DDN Homo sapiens O94850
Pull Down
16751601
Intra SH3KBP1 Q96B97 NELFA Homo sapiens Q9H3P2
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 NELFA Homo sapiens Q9H3P2
Validated Y2H
32296183
Intra SH3KBP1 Q96B97 NELFA Homo sapiens Q9H3P2
Y2H Array
32296183
Intra SH3KBP1 Q96B97 STAP1 Homo sapiens Q9ULZ2
Y2H
21516116
Cross SH3KBP1 Q96B97 Hip1r Mus musculus Q9JKY5
Anti Tag CoIP
15090612
Intra SH3KBP1 Q96B97 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra SH3KBP1 Q96B97 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra SH3KBP1 Q96B97 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SH3KBP1 Q96B97 SH3BP2 Homo sapiens P78314
Pull Down
17306257
Intra SH3KBP1 Q96B97 SH3BP2 Homo sapiens P78314
Anti Tag CoIP
17306257
Intra SH3KBP1 Q96B97 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra SH3KBP1 Q96B97 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra SH3KBP1 Q96B97 SPRY2 Homo sapiens O43597
Anti Bait CoIP
15962011
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
Anti Bait CoIP
12177062
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
NMR
19268472
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
SAXS
23663663
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
NMR
23663663
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
ITC
19268472
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
ITC
23663663
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
ELISA
12829691
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
Y2H Array
32296183
Intra SH3KBP1 Q96B97 CBLB Homo sapiens Q13191
Competition Binding
18680311
Intra SH3KBP1 Q96B97 SH3GL2 Homo sapiens Q99962
Anti Tag CoIP
11894095
Intra SH3KBP1 Q96B97 SH3GL2 Homo sapiens Q99962
Anti Bait CoIP
11894095
Intra SH3KBP1 Q96B97 SH3GL2 Homo sapiens Q99962
Pull Down
16164598
Intra SH3KBP1 Q96B97 q7z783_human Homo sapiens Q7Z783
Y2H Prey Pooling
32296183
Intra SH3KBP1 Q96B97 q7z783_human Homo sapiens Q7Z783
Y2H Array
32296183
Cross SH3KBP1 Q96B97 Dnm2 Rattus norvegicus P39052
Pull Down
20711168
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 61

Agammaglobulinemia, X-Linked, Type 2

IMD61

Agmx2

Xla2

Agammaglobulinemia X-Linked Type 2

Agammaglobulinemia, X-Linked 2
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma
Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome

Shah-Waardenburg Syndrome

Waardenburg Syndrome Type 4a

WS4A

Ws4

Waardenburg Syndrome Type 4

Waardenburg Syndrome Type Iva

Waardenburg Syndrome With Hirschsprung Disease Type 4a

Hirschsprung Disease With Pigmentary Anomaly

Waardenburg-Hirschsprung Syndrome

Waardenburg Syndrome, Type Iva

Waardenburg Syndrome With Hirschsprung Disease, Type 4a

Waardenburg-Hirschsprung Disease

Waardenburg Syndrome, Type 4

Waardenburg Syndrome 4a
Oculoauricular Syndrome

OCACS

Schorderet-Munier-Franceschetti Syndrome

Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear

Oculoauricular Syndrome, Schorderet Type

Oculo-Auricular Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12841 SH3KBP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SH3KBP1 VGNC VGNC:77227
Canis familiaris SH3KBP1 VGNC VGNC:46129
Bos taurus SH3KBP1 VGNC VGNC:34577
Rattus norvegicus SH3KBP1 RGD RGD:620904
Mus musculus SH3KBP1 MGD MGI:1889583
Felis catus SH3KBP1 VGNC VGNC:65111