KCTD5 - potassium channel tetramerization domain containing 5 Gene

Homo sapiens

Gene ID: 54442 | Gene type: protein coding

About KCTD5

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,682,523-2,709,030 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 15.1), esophagus (RPKM 11.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

KCTD5 Products(1)

mRNA	Protein	Name
NM_018992.4	NP_061865.1	BTB/POZ domain-containing protein KCTD5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27152988	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17239418	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	23209302	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	18573101	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD5 Protein Structure

BTB_2

0
100
200
234 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing protein KCTD5

potassium channel tetramerisation domain containing 5

KCTD5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCTD5	Q9NXV2	GIT2	Homo sapiens	Q14161	Y2H Array	21988832
Intra	KCTD5	Q9NXV2	KCTD5	Homo sapiens	Q9NXV2	EM	27152988
Intra	KCTD5	Q9NXV2	KCTD5	Homo sapiens	Q9NXV2	GMS	27152988
Intra	KCTD5	Q9NXV2	CD1A	Homo sapiens	P06126	Y2H Array	21988832
Intra	KCTD5	Q9NXV2	Rep78	Adeno-associated virus 2	Q89268	IF	17239418
Intra	KCTD5	Q9NXV2	Rep78	Adeno-associated virus 2	Q89268	Anti Bait CoIP	17239418
Cross	KCTD5	Q9NXV2	Rep68	Adeno-associated virus 2	P03132	Anti Bait CoIP	17239418

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome	Sen Syndrome
SENS	Scalp Ear Nipple Syndrome
Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples	Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples
Indian Childhood Cirrhosis

Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome	BOFS
Bof Syndrome	Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome
Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome	Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging
Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging	Bofs Syndrome
Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07197	KCTD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KCTD5	VGNC	VGNC:73876
Mus musculus	KCTD5	MGD	MGI:1916509
Canis familiaris	KCTD5	VGNC	VGNC:42309
Felis catus	KCTD5	VGNC	VGNC:97472
Rattus norvegicus	KCTD5	RGD	RGD:1304990
Bos taurus	KCTD5	VGNC	VGNC:30513

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