2. Gene
  3. GIT2 - GIT ArfGAP 2 Gene

GIT2 - GIT ArfGAP 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PKL; CAT2; CAT-2

Gene ID: 9815 | Gene type: protein coding

About GIT2

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,929,804-110,000,164 (from NCBI)

This gene has 19 transcripts (splice variants), 275 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 15.0), lymph node (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with PAK interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit Other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

GIT2 Products(8)

mRNA Protein Name
NM_001135213.3 NP_001128685.1 ARF GTPase-activating protein GIT2 isoform 6
NM_001135214.3 NP_001128686.1 ARF GTPase-activating protein GIT2 isoform 5
NM_001330153.2 NP_001317082.1 ARF GTPase-activating protein GIT2 isoform 7
NM_001330154.2 NP_001317083.1 ARF GTPase-activating protein GIT2 isoform 8
NM_014776.5 NP_055591.2 ARF GTPase-activating protein GIT2 isoform 3
NM_057169.5 NP_476510.1 ARF GTPase-activating protein GIT2 isoform 1
NM_057170.5 NP_476511.1 ARF GTPase-activating protein GIT2 isoform 2
NM_139201.3 NP_631940.2 ARF GTPase-activating protein GIT2 isoform 4
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16628223 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
10942595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GIT2 Protein Structure

ArfGap

ArfGap: Putative GTPase activating protein for Arf (6 - 118)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (137 - 226)

GIT_SHD

GIT_SHD: Spa2 homology domain (SHD) of GIT (266 - 296)

GIT_SHD

GIT_SHD: Spa2 homology domain (SHD) of GIT (330 - 359)

GIT1_C

GIT1_C: G protein-coupled receptor kinase-interacting protein 1 C term (633 - 754)

  • 0
  • 200
  • 400
  • 600
  • 759 a.a.
Protein Preferred Names Protein Names

ARF GTPase-activating protein GIT2

ARF GAP GIT2

GIT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GIT2 Q14161 TSN Homo sapiens Q15631
Anti Tag CoIP
21988832
Intra
GIT2 Q14161 PAK1 Homo sapiens Q13153
Anti Bait CoIP
16628223
Intra
GIT2 Q14161 TNIP1 Homo sapiens Q15025
Y2H Array
21988832
Intra
GIT2 Q14161 TNIP1 Homo sapiens Q15025
Anti Tag CoIP
21988832
Intra
GIT2 Q14161 TRAF1 Homo sapiens Q13077
Anti Tag CoIP
21988832
Intra
GIT2 Q14161 GIT1 Homo sapiens Q9Y2X7
Anti Tag CoIP
33961781
Intra
GIT2 Q14161 GIT1 Homo sapiens Q9Y2X7
Anti Bait CoIP
16628223
Cross
GIT2 Q14161 Arhgef7 Mus musculus Q9ES28
Pull Down
21295525
Intra
GIT2 Q14161 PXN Homo sapiens P49023
Anti Bait CoIP
16628223
Intra
GIT2 Q14161 ARHGEF7 Homo sapiens Q14155
Anti Tag CoIP
33961781
Intra
GIT2 Q14161 IKBKG Homo sapiens Q9Y6K9
Y2H
21988832
Intra
GIT2 Q14161 IKBKG Homo sapiens Q9Y6K9
Anti Tag CoIP
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Esophagus Verrucous Carcinoma

Oesophagus Verrucous Carcinoma

Verrucous Carcinoma Of Esophagus

Verrucous Carcinoma Of Oesophagus

Verrucous Carcinoma Of The Esophagus
Blind Loop Syndrome

Bacterial Overgrowth Syndrome
Systemic Scleroderma

Scleroderma

Progressive Systemic Sclerosis

Systemic Sclerosis

Scleroderma, Systemic

Scleroderma Syndrome

Dermatosclerosis

Familial Progressive Scleroderma

Progressive Scleroderma

Scleroderma Disease

Scleroderma, Localized

Diffuse Scleroderma

Scleroderma, Familial Progressive
Pneumatosis Cystoides Intestinalis
Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05439 GIT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GIT2 VGNC VGNC:41230
Bos taurus GIT2 VGNC VGNC:29369
Macaca mulatta GIT2 VGNC VGNC:73054
Mus musculus GIT2 MGD MGI:1347053
Felis catus GIT2 VGNC VGNC:62561
Rattus norvegicus GIT2 RGD RGD:1359708