ZFAND6 - zinc finger AN1-type containing 6 Gene

Homo sapiens

Also known as AWP1; ZA20D3; ZFAND5B

Gene ID: 54469 | Gene type: protein coding

About ZFAND6

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:80,058,951-80,138,393 (from NCBI)

This gene has 24 transcripts (splice variants), 151 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 50.8), thyroid (RPKM 41.4) and 25 other tissues.

Summary

Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ZFAND6 Products(10)

mRNA	Protein	Name
NM_001242911.2	NP_001229840.1	AN1-type zinc finger protein 6 isoform a
NM_001242912.2	NP_001229841.1	AN1-type zinc finger protein 6 isoform a
NM_001242913.2	NP_001229842.1	AN1-type zinc finger protein 6 isoform a
NM_001242914.2	NP_001229843.1	AN1-type zinc finger protein 6 isoform a
NM_001242915.2	NP_001229844.1	AN1-type zinc finger protein 6 isoform a
NM_001242916.2	NP_001229845.1	AN1-type zinc finger protein 6 isoform a
NM_001242917.2	NP_001229846.1	AN1-type zinc finger protein 6 isoform b
NM_001242918.2	NP_001229847.1	AN1-type zinc finger protein 6 isoform c
NM_001242919.1	NP_001229848.1	AN1-type zinc finger protein 6 isoform d
NM_019006.4	NP_061879.2	AN1-type zinc finger protein 6 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	21810480	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21810480	GOA
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21810480	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFAND6 Protein Structure

zf-A20

zf-AN1

0
100
208 a.a.

Protein Preferred Names

Protein Names

AN1-type zinc finger protein 6

protein associated with PRK1

ZFAND6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFAND6	Q6FIF0	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	33961781
Intra	ZFAND6	Q6FIF0	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	21810480
Intra	ZFAND6	Q6FIF0	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21810480
Intra	ZFAND6	Q6FIF0	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	ZFAND6	Q6FIF0	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	25416956
Intra	ZFAND6	Q6FIF0	TRAF5	Homo sapiens	O00463	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16032	ZFAND6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZFAND6	RGD	RGD:1359317
Canis familiaris	ZFAND6	VGNC	VGNC:103715
Bos taurus	ZFAND6	VGNC	VGNC:107038
Mus musculus	ZFAND6	MGD	MGI:1929510

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