2. Gene
  3. MIER2 - MIER family member 2 Gene

MIER2 - MIER family member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Mi-er2; KIAA1193

Gene ID: 54531 | Gene type: protein coding

About MIER2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:305,573-344,796 (from NCBI)

This gene has 7 transcripts (splice variants), 183 orthologues and 5 paralogues. Broad expression in testis (RPKM 6.0), spleen (RPKM 3.4) and 25 other tissues.

Summary

Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Involved in histone deacetylation. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

MIER2 Products(8)

mRNA Protein Name
NM_001346105.2 NP_001333034.1 mesoderm induction early response protein 2 isoform 2
NM_001387152.1 NP_001374081.1 mesoderm induction early response protein 2 isoform 3
NM_001387153.1 NP_001374082.1 mesoderm induction early response protein 2 isoform 4
NM_001387154.1 NP_001374083.1 mesoderm induction early response protein 2 isoform 5
NM_001387155.1 NP_001374084.1 mesoderm induction early response protein 2 isoform 2
NM_001387156.1 NP_001374085.1 mesoderm induction early response protein 2 isoform 6
NM_001387157.1 NP_001374086.1 mesoderm induction early response protein 2 isoform 6
NM_017550.3 NP_060020.1 mesoderm induction early response protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to histone deacetylase activity IDA
IDA: Inferred from direct assay
28046085 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
28046085 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28046085 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28046085 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28046085 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIER2 Protein Structure

ELM2

ELM2: ELM2 domain (197 - 248)

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  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

mesoderm induction early response protein 2

mesoderm induction early response 1, family member 2

MIER2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MIER2 Q8N344 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08443 MIER2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MIER2 RGD RGD:1307278
Macaca mulatta MIER2 VGNC VGNC:74855
Mus musculus MIER2 MGD MGI:1917677
Felis catus MIER2 VGNC VGNC:63501
Canis familiaris MIER2 VGNC VGNC:43230
Bos taurus MIER2 VGNC VGNC:31470