MCRS1 - microspherule protein 1 Gene

Homo sapiens

Also known as P78; MCRS2; MSP58; INO80Q; ICP22BP

Gene ID: 10445 | Gene type: protein coding

About MCRS1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,558,299-49,568,142 (from NCBI)

This gene has 16 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in heart (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues.

Summary

Enables RNA binding activity and Telomerase Inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

MCRS1 Products(3)

mRNA	Protein	Name
NM_001012300.1	NP_001012300.1	microspherule protein 1 isoform 2
NM_001278341.2	NP_001265270.1	microspherule protein 1 isoform 3
NM_006337.5	NP_006328.2	microspherule protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-quadruplex RNA binding	IDA IDA: Inferred from direct assay	16571602	GOA
enables poly(G) binding	IDA IDA: Inferred from direct assay	16571602	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	16571602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11948183	GOA
enables telomerase inhibitor activity	IDA IDA: Inferred from direct assay	15044100	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in negative regulation of telomere maintenance via telomere lengthening	IDA IDA: Inferred from direct assay	15044100	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in positive regulation of protein localization to nucleolus	IDA IDA: Inferred from direct assay	16571602	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	21303910	GOA
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
part of NSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16571602	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16571602	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16571602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCRS1 Protein Structure

MCRS_N

FHA

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

microspherule protein 1

58 kDa microspherule protein

Related Diseases

Diseases

Alias

Pigmented Basal Cell Carcinoma

Skin Pigmented Basal Cell Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08248	MCRS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCRS1	VGNC	VGNC:43093
Rattus norvegicus	MCRS1	RGD	RGD:1311607
Macaca mulatta	MCRS1	VGNC	VGNC:74688
Mus musculus	MCRS1	MGD	MGI:1858420
Bos taurus	MCRS1	VGNC	VGNC:31323

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