TOMM7 - translocase of outer mitochondrial membrane 7 Gene

Homo sapiens

Also known as TOM7

Gene ID: 54543 | Gene type: protein coding

About TOMM7

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:22,812,974-22,822,849 (from NCBI)

This gene has 6 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in ovary (RPKM 141.3), fat (RPKM 120.2) and 25 other tissues.

Summary

This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]

TOMM7 Products(1)

mRNA	Protein	Name
NM_019059.5	NP_061932.1	mitochondrial import receptor subunit TOM7 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12198123	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	24270810	GOA
involved in positive regulation of type 2 mitophagy	IMP IMP: Inferred from mutant phenotype	24270810	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	24270810	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial outer membrane translocase complex	IDA IDA: Inferred from direct assay	12198123	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	12198123	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOMM7 Protein Structure

Tom7

0
55 a.a.

Protein Preferred Names

Protein Names

mitochondrial import receptor subunit TOM7 homolog

translocase of outer membrane 7 kDa subunit homolog

Related Diseases

Diseases

Alias

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14886	TOMM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TOMM7	MGD	MGI:1913419
Felis catus	TOMM7	VGNC	VGNC:102724
Canis familiaris	TOMM7	VGNC	VGNC:54798
Macaca mulatta	TOMM7	VGNC	VGNC:108450
Rattus norvegicus	TOMM7	RGD	RGD:1591393

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